Gene and cytokine profile analysis of macrolide-resistant Mycoplasma pneumoniaeinfection in Fukuoka, Japan

BMC Infectious Diseases

Table 1 Comparison of clinical characteristics in patients infected by M. pneumoniae according to the genotypes

	A2063G (n = 31)	A2063T (n = 27)	No mutation (n = 7)	p*	P1	P2	P3
Age (years)	7.0 (4.0 – 9.5)	7.0 (4.5 – 8.0)	4.0 (3.0 – 7.5)	ns
Gender (M/F)	14 / 17	15 / 12	3 / 4	ns
Day exam performed	4 (4 – 6)	5 (4 – 5)	5 ( 4 – 5)	ns
WBC	5850	6200	6350	ns
(/μl)	(5050–6250)	(5650–7075)	(5375–6800)	ns
CRP	1.35	0.90	1.75	ns
(mg/dL)	(0.90 - 1.95)	(0.53 -2.48)	(0.63 - 4.08)	ns
ESR	29.0	30.0	34.5	ns
(mm/hr)	(22.75 - 40.50)	(22.0 - 44.25)	(25.25 - 52.0)	ns
IL-8	14.2	20.1	29.88	ns
(pg/mL)	(9.1 - 34.3)	(15.2- 26.0)	(18.4 - 84.8)	ns
IL-18	457.0	477.7	533.8	ns
(pg/mL)	(410.2 - 571.6)	(362.5 - 564.2)	(420.9 - 629.8)	ns
IFN-γ	15.9	18.1	11.5	< 0.001	< 0.001	< 0.001	ns
(pg/mL)	(10.4 – 27.2)	(4.7 – 38.6)	(8.8 – 12.7)	< 0.001	< 0.001	< 0.001	ns
IP-10	1019	931	643.5	< 0.001	< 0.001	< 0.001	ns
(pg/mL)	(794–1378)	(659 – 1519.5)	(550.7 – 873.0)	< 0.001	< 0.001	< 0.001	ns
IL-6	6.57	7.79	5.86	< 0.001	< 0.001	< 0.001	ns
(pg/mL)	(2.77 – 13.73)	(3.34 – 16.38)	(3.16 – 11.58)	< 0.001	< 0.001	< 0.001	ns
Initial antibiotics used
none	0	1	1
β-lactam	3	3	0
14-macrolide	13	11	3
15-macrolide	13	10	3
Quinolones	0	1	0
Minocycline	2	0	0
Secondary antibiotics used
14-macrolide	1	0	0
15-macrolide	2	7	0
Quinolones	2	1	0
Minocycline	26	16	2
Total duration of fever (days)	7.0 (5.0 – 8.0)	7.0 (5.5 – 8.0)	5.0 (5.0 – 5.5)	p* = 0.04	P1 = 0.03	P2 = 0.01	P3 = ns
Number of patients for whom non-macrolide antibiotics were used as secondary antibiotics	28 (90.3%)	17 (63.0%)	2 (28.6%)	p* = 0.001	P1 = 0.001	P2 = ns	P3 = 0.02
Number of patients requiring hospitalization	1 (3.2%)	1 (3.7%)	0 (0%)	ns

Data represent medians (1st quantile - 3rd quantile). The Kruskal-Wallis test and Fisher exact test were used to compare the three groups. Wilcoxon test was used to assess pairwise difference.
p*: comparison of A2063G, A2063T and no mutation.
P1, P2, P3: comparison of A2063G vs. no mutation, A2063T vs. no mutation, and A2063G vs. A2063T, respectively.

ISSN: 1471-2334