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Table 8 Genotype distribution on our independent cohort which included 110 ASY controls and 281 cases (CCC) taking into account the gender and the left ventricular ejection fraction values

From: Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways

    ASY CCC CCC (EF ≤ 0.4) CCC (EF ≥ 0.4)
Gene SNP Genotype  Total  Male Female  Total  Male Female  Total  Male Female  Total  Male Female
CCL2 rs3760396 GG 61 30 30 208 128 79 140 99 41 76 28 36
(81.3%) (81.1%) (81.1%) (80.0%) (80.9%) (76.7%) (78.7%) (80.5%) (74.5%) (86.4%) (93.3%) (78.3%)
   GC 13 6 7 50 26 23 37 23 14 11 2 9
(17.3%) (16.2%) (18.9%) (19.4%) (19.2%) (22.3%) (20.8%) (18.7%) (25.5%) (12.5%) (6.7%) (19.6%)
   CC 1 1 0 2 1 1 1 1 0 1 0 1
(1.4%) (2.7%) (0.0%) (0.6%) (0.9%) (1.0%) (0.5%) (0.8%) (0.0%) (1.1%) (0.0%) (2.1%)
CCL2 rs2857656 CC 34 16 17 101 57 42 71 46 25 28 11 17
(46.6%) (44,4%) (47,2%) (38.7%) (36.8%) (42.0%) (39.9%) (37,4%) (45.5%) (36,4%) (36,7%) (36,2%)
   CG 36 20 16 133 59 54 86 62 24 45 16 29
(49.3%) (55,6%) (44,4%) (51%) (51%) (51,9%) (48,3%) (50,4%) (43.6%) (58,4%) (53,3%) (61,7%)
   GG 3 0 3 27 19 8 21 15 6 4 3 1
(4,1%) (0%) (8,3%) (10.3%) (12.3%) (7,7%) (11.8%) (12.2%) (10.9%) (5,2%) (10%) (2,1%)
CCL2 rs4586 TT 23 13 10 62 34 27 44 29 15 17 5 12
(32,4%) (37,1%) (28,6%) (23,8%) (21.8%) (26,5%) (24,6%) (23,4%) (27.3%) (22,4%) (16,7%) (26,1%)
   TC 39 20 18 130 78 51 84 60 24 44 17 27
(54,9%) (57,1%) (51,4%) (50%) (50%) (50%) (46,9%) (48,4%) (43.6%) (57,9%) (56,7%) (58,7%)
   CC 9 2 7 68 44 24 51 35 16 15 8 7
(12,7%) (5,7%) (20%) (22.2%) (28,2%) (23.5%) (28.5%) (28.2%) (29.1%) (19,7%) (26,7%) (15,2%)
CCL2 rs3917891 CC 69 34 34 220 132 86 150 104 46 66 27 39
(92%) (89,5%) (94,4%) (84.9%) (85,2%) (84,3%) (84,7%) (84,6%) (85.2%) (86,8%) (90%) (84,8%)
   CT 6 4 2 37 22 15 25 18 7 10 3 7
(8%) (10,5%) (5,6%) (14,3%) (14,2%) (14,7%) (14,1%) (14.6%) (13.0%) (13,2%) (10%) (15,2%)
   TT 0 0 0 2 1 1 2 1 1 0 0 0
(0%) (0%) (0.0%) (0.8%) (0.6%) (1%) (1.1%) (0.8%) (1.9%) (0.0%) (0.0%) (0.0%)
CCL2 rs2530797 AA 25 7 17 132 81 50 96 67 29 32 12 20
(33.8%) (18.9%) (47.2%) (50.6%) (51.9%) (48.5%) (53.6%) (54.0%) (52,7%) (41.6%) (40.0%) (42.6%)
   AG 40 26 14 104 62 41 65 47 18 38 15 23
(54.1%) (70.3%) (38.9%) (39.8%) (39.7%) (39.8%) (36.3%) (37.9%) (32.7%) (49.4%) (50%) (48.9%)
   GG 9 4 5 25 13 12 18 10 8 7 3 4
(12.2%) (10.8%) (13.9%) (9.6%) (8.3%) (11.7%) (10.1%) (8.1%) (14,5%) (9.1%) (10.0%) (8.5%)
CCL2 rs991804 CC 35 16 18 99 55 42 71 45 26 26 10 16
(47.6%) (42,1%) (50%) (40,9%) (38.7%) (42,9%) (43%) (39.5%) (51.0%) (36,1%) (37%) (35,6%)
   CT 36 21 15 122 72 50 77 56 21 43 15 28
(48%) (55,3%) (41,7%) (50.4%) (50,7%) (51%) (46,7%) (49,1%) (41.2%) (59,7%) (55.6%) (62,2%)
   TT 4 1 3 21 15 6 17 13 4 3 2 1
(5,3%) (2,6%) (8.3%) (8,7%) (10,6%) (6.1%) (10.3%) (11,4%) (7.8%) (4,2%) (7.4%) (2,2%)
TIRAP rs11220437 TT 61 30 30 189 114 73 132 92 40 51 20 31
(81,3%) (79,8%) (83,3%) (73.0%) (73,5%) (71,6%) (74,2%) (74,2%) (74.1%) (68%) (69%) (67,4%)
   TC 13 8 5 65 38 27 42 30 12 23 8 15
(17,3%) (21,1%) (13,9%) (25,1%) (24,5%) (26.5%) (23,6%) (24,2%) (22.2%) (30,7%) (27,6%) (32,6%)
   CC 1 0 1 5 3 2 4 2 2 1 1 0
(1,3%) (0.0%) (2,8%) (1.9%) (1.9%) (2%) (2.2%) (1.6%) (3.7%) (1.3%) (3.4%) (0.0%)
TIRAP rs591163 GG 27 14 13 132 77 54 91 61 30 40 16 24
(38%) (40%) (37,1%) (50,8%) (49,7%) (52,4%) (51,4%) (49,6%) (55,6%) (51.9%) (53,3%) (51,1%)
   GA 33 15 17 103 63 39 70 51 19 29 11 18
(46,5%) (42,9%) (48,6%) (39.6%) (40,6%) (37,9%) (39,5%) (41,5%) (35,2%) (37.7%) (36,7%) (38,3%)
   AA 11 6 5 25 15 10 16 11 5 8 3 5
(15,5%) (17,1%) (14,3%) (9.6%) (9.7%) (9,7%) (9%) (8.9%) (9,3%) (10.4%) (10%) (10,6%)
TIRAP rs8177352 AA 59 30 28 192 111 79 129 87 42 59 22 37
(80,8%) (81,1%) (80%) (74,1%) (71.6%) (77.5%) (72,5%) (70,7%) (76.4%) (77.6%) (73,3%) (80,4%)
   AG 13 6 7 58 37 21 40 29 11 17 8 9
(17.8%) (16,2%) (20%) (22,4%) (23,9%) (20,6%) (22,5%) (23,6%) (20.0%) (22.4%) (26,7%) (19,6%)
   GG 1 1 0 9 7 2 9 7 2 0 0 0
(1.4%) (2,7%) (0%) (3,5%) (4,5%) (2%) (5,1%) (5.7%) (3.6%) (0.0%) (0.0%) (0.0%)
TIRAP rs8177375 AA 61 32 28 203 124 77 140 99 41 58 24 34
(83,6%) (86,5%) (80%) (77,8%) (80%) (74%) (78,7%) (80,5%) (74.5%) (75,3%) (80%) (72,3%)
   AG 10 4 6 54 29 25 36 23 13 17 5 12
(13,7%) (10,8%) (17,1%) (20,7%) (18,7%) (24%) (20,2%) (18.7%) (23.6%) (22,1%) (16,7%) (25,5%)
   GG 2 1 1 4 2 2 2 1 1 2 1 1
(2,7%) (2,7%) (2,9%) (1.5%) (1.3%) (1.9%) (1.1%) (0.8%) (1.8%) (2,6%) (3,3%) (2,1%)
TIRAP rs8177376 AA 42 19 23 195 121 72 134 95 39 56 24 32
(61,8%) (59,4%) (63,9%) (75,6%) (78,6%) (70,6%) (75,7%) (77,9%) (70.9%) (73,3%) (80%) (69,6%)
   AC 25 13 12 60 32 28 42 26 16 18 6 12
(36,8%) (40.6%) (33,3%) (23.3%) (20,8%) (27,5%) (23,7%) (21,3%) (29.1%) (23,7%) (20%) (26,1%)
   CC 1 0 1 3 1 2 1 1 0 2 0 2
(1,5%) (0%) (2,8%) (1.2%) (0.6%) (2%) (0.6%) (0.8%) (0.0%) (2,6%) (0.0%) (4.3%)
TIRAP rs17866704 TT 54 27 26 150 85 71 105 70 35 41 14 27
(72%) (75%) (68,4%) (58,4%) (55,2%) (60.7%) (59,7%) (57,4%) (64.8%) (54,7%) (46,7%) (60%)
   TC 20 9 11 88 55 41 59 42 17 27 12 15
(26,7%) (25%) (28,9%) (34,2%) (35,7%) (35.0%) (33,5%) (34,4%) (31.5%) (36%) (40%) (33,3%)
   CC 1 0 1 19 14 5 12 10 2 7 4 3
(1,3%) (0.0%) (2.6%) (7,4%) (9,1%) (4.3%) (6,8%) (8,2%) (3.7%) (9,3%) (13,3%) (6,7%)