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Table 8 Genotype distribution on our independent cohort which included 110 ASY controls and 281 cases (CCC) taking into account the gender and the left ventricular ejection fraction values

From: Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways

   

ASY

CCC

CCC (EF ≤ 0.4)

CCC (EF ≥ 0.4)

Gene

SNP

Genotype

 Total

 Male

Female

 Total

 Male

Female

 Total

 Male

Female

 Total

 Male

Female

CCL2

rs3760396

GG

61

30

30

208

128

79

140

99

41

76

28

36

(81.3%)

(81.1%)

(81.1%)

(80.0%)

(80.9%)

(76.7%)

(78.7%)

(80.5%)

(74.5%)

(86.4%)

(93.3%)

(78.3%)

  

GC

13

6

7

50

26

23

37

23

14

11

2

9

(17.3%)

(16.2%)

(18.9%)

(19.4%)

(19.2%)

(22.3%)

(20.8%)

(18.7%)

(25.5%)

(12.5%)

(6.7%)

(19.6%)

  

CC

1

1

0

2

1

1

1

1

0

1

0

1

(1.4%)

(2.7%)

(0.0%)

(0.6%)

(0.9%)

(1.0%)

(0.5%)

(0.8%)

(0.0%)

(1.1%)

(0.0%)

(2.1%)

CCL2

rs2857656

CC

34

16

17

101

57

42

71

46

25

28

11

17

(46.6%)

(44,4%)

(47,2%)

(38.7%)

(36.8%)

(42.0%)

(39.9%)

(37,4%)

(45.5%)

(36,4%)

(36,7%)

(36,2%)

  

CG

36

20

16

133

59

54

86

62

24

45

16

29

(49.3%)

(55,6%)

(44,4%)

(51%)

(51%)

(51,9%)

(48,3%)

(50,4%)

(43.6%)

(58,4%)

(53,3%)

(61,7%)

  

GG

3

0

3

27

19

8

21

15

6

4

3

1

(4,1%)

(0%)

(8,3%)

(10.3%)

(12.3%)

(7,7%)

(11.8%)

(12.2%)

(10.9%)

(5,2%)

(10%)

(2,1%)

CCL2

rs4586

TT

23

13

10

62

34

27

44

29

15

17

5

12

(32,4%)

(37,1%)

(28,6%)

(23,8%)

(21.8%)

(26,5%)

(24,6%)

(23,4%)

(27.3%)

(22,4%)

(16,7%)

(26,1%)

  

TC

39

20

18

130

78

51

84

60

24

44

17

27

(54,9%)

(57,1%)

(51,4%)

(50%)

(50%)

(50%)

(46,9%)

(48,4%)

(43.6%)

(57,9%)

(56,7%)

(58,7%)

  

CC

9

2

7

68

44

24

51

35

16

15

8

7

(12,7%)

(5,7%)

(20%)

(22.2%)

(28,2%)

(23.5%)

(28.5%)

(28.2%)

(29.1%)

(19,7%)

(26,7%)

(15,2%)

CCL2

rs3917891

CC

69

34

34

220

132

86

150

104

46

66

27

39

(92%)

(89,5%)

(94,4%)

(84.9%)

(85,2%)

(84,3%)

(84,7%)

(84,6%)

(85.2%)

(86,8%)

(90%)

(84,8%)

  

CT

6

4

2

37

22

15

25

18

7

10

3

7

(8%)

(10,5%)

(5,6%)

(14,3%)

(14,2%)

(14,7%)

(14,1%)

(14.6%)

(13.0%)

(13,2%)

(10%)

(15,2%)

  

TT

0

0

0

2

1

1

2

1

1

0

0

0

(0%)

(0%)

(0.0%)

(0.8%)

(0.6%)

(1%)

(1.1%)

(0.8%)

(1.9%)

(0.0%)

(0.0%)

(0.0%)

CCL2

rs2530797

AA

25

7

17

132

81

50

96

67

29

32

12

20

(33.8%)

(18.9%)

(47.2%)

(50.6%)

(51.9%)

(48.5%)

(53.6%)

(54.0%)

(52,7%)

(41.6%)

(40.0%)

(42.6%)

  

AG

40

26

14

104

62

41

65

47

18

38

15

23

(54.1%)

(70.3%)

(38.9%)

(39.8%)

(39.7%)

(39.8%)

(36.3%)

(37.9%)

(32.7%)

(49.4%)

(50%)

(48.9%)

  

GG

9

4

5

25

13

12

18

10

8

7

3

4

(12.2%)

(10.8%)

(13.9%)

(9.6%)

(8.3%)

(11.7%)

(10.1%)

(8.1%)

(14,5%)

(9.1%)

(10.0%)

(8.5%)

CCL2

rs991804

CC

35

16

18

99

55

42

71

45

26

26

10

16

(47.6%)

(42,1%)

(50%)

(40,9%)

(38.7%)

(42,9%)

(43%)

(39.5%)

(51.0%)

(36,1%)

(37%)

(35,6%)

  

CT

36

21

15

122

72

50

77

56

21

43

15

28

(48%)

(55,3%)

(41,7%)

(50.4%)

(50,7%)

(51%)

(46,7%)

(49,1%)

(41.2%)

(59,7%)

(55.6%)

(62,2%)

  

TT

4

1

3

21

15

6

17

13

4

3

2

1

(5,3%)

(2,6%)

(8.3%)

(8,7%)

(10,6%)

(6.1%)

(10.3%)

(11,4%)

(7.8%)

(4,2%)

(7.4%)

(2,2%)

TIRAP

rs11220437

TT

61

30

30

189

114

73

132

92

40

51

20

31

(81,3%)

(79,8%)

(83,3%)

(73.0%)

(73,5%)

(71,6%)

(74,2%)

(74,2%)

(74.1%)

(68%)

(69%)

(67,4%)

  

TC

13

8

5

65

38

27

42

30

12

23

8

15

(17,3%)

(21,1%)

(13,9%)

(25,1%)

(24,5%)

(26.5%)

(23,6%)

(24,2%)

(22.2%)

(30,7%)

(27,6%)

(32,6%)

  

CC

1

0

1

5

3

2

4

2

2

1

1

0

(1,3%)

(0.0%)

(2,8%)

(1.9%)

(1.9%)

(2%)

(2.2%)

(1.6%)

(3.7%)

(1.3%)

(3.4%)

(0.0%)

TIRAP

rs591163

GG

27

14

13

132

77

54

91

61

30

40

16

24

(38%)

(40%)

(37,1%)

(50,8%)

(49,7%)

(52,4%)

(51,4%)

(49,6%)

(55,6%)

(51.9%)

(53,3%)

(51,1%)

  

GA

33

15

17

103

63

39

70

51

19

29

11

18

(46,5%)

(42,9%)

(48,6%)

(39.6%)

(40,6%)

(37,9%)

(39,5%)

(41,5%)

(35,2%)

(37.7%)

(36,7%)

(38,3%)

  

AA

11

6

5

25

15

10

16

11

5

8

3

5

(15,5%)

(17,1%)

(14,3%)

(9.6%)

(9.7%)

(9,7%)

(9%)

(8.9%)

(9,3%)

(10.4%)

(10%)

(10,6%)

TIRAP

rs8177352

AA

59

30

28

192

111

79

129

87

42

59

22

37

(80,8%)

(81,1%)

(80%)

(74,1%)

(71.6%)

(77.5%)

(72,5%)

(70,7%)

(76.4%)

(77.6%)

(73,3%)

(80,4%)

  

AG

13

6

7

58

37

21

40

29

11

17

8

9

(17.8%)

(16,2%)

(20%)

(22,4%)

(23,9%)

(20,6%)

(22,5%)

(23,6%)

(20.0%)

(22.4%)

(26,7%)

(19,6%)

  

GG

1

1

0

9

7

2

9

7

2

0

0

0

(1.4%)

(2,7%)

(0%)

(3,5%)

(4,5%)

(2%)

(5,1%)

(5.7%)

(3.6%)

(0.0%)

(0.0%)

(0.0%)

TIRAP

rs8177375

AA

61

32

28

203

124

77

140

99

41

58

24

34

(83,6%)

(86,5%)

(80%)

(77,8%)

(80%)

(74%)

(78,7%)

(80,5%)

(74.5%)

(75,3%)

(80%)

(72,3%)

  

AG

10

4

6

54

29

25

36

23

13

17

5

12

(13,7%)

(10,8%)

(17,1%)

(20,7%)

(18,7%)

(24%)

(20,2%)

(18.7%)

(23.6%)

(22,1%)

(16,7%)

(25,5%)

  

GG

2

1

1

4

2

2

2

1

1

2

1

1

(2,7%)

(2,7%)

(2,9%)

(1.5%)

(1.3%)

(1.9%)

(1.1%)

(0.8%)

(1.8%)

(2,6%)

(3,3%)

(2,1%)

TIRAP

rs8177376

AA

42

19

23

195

121

72

134

95

39

56

24

32

(61,8%)

(59,4%)

(63,9%)

(75,6%)

(78,6%)

(70,6%)

(75,7%)

(77,9%)

(70.9%)

(73,3%)

(80%)

(69,6%)

  

AC

25

13

12

60

32

28

42

26

16

18

6

12

(36,8%)

(40.6%)

(33,3%)

(23.3%)

(20,8%)

(27,5%)

(23,7%)

(21,3%)

(29.1%)

(23,7%)

(20%)

(26,1%)

  

CC

1

0

1

3

1

2

1

1

0

2

0

2

(1,5%)

(0%)

(2,8%)

(1.2%)

(0.6%)

(2%)

(0.6%)

(0.8%)

(0.0%)

(2,6%)

(0.0%)

(4.3%)

TIRAP

rs17866704

TT

54

27

26

150

85

71

105

70

35

41

14

27

(72%)

(75%)

(68,4%)

(58,4%)

(55,2%)

(60.7%)

(59,7%)

(57,4%)

(64.8%)

(54,7%)

(46,7%)

(60%)

  

TC

20

9

11

88

55

41

59

42

17

27

12

15

(26,7%)

(25%)

(28,9%)

(34,2%)

(35,7%)

(35.0%)

(33,5%)

(34,4%)

(31.5%)

(36%)

(40%)

(33,3%)

  

CC

1

0

1

19

14

5

12

10

2

7

4

3

(1,3%)

(0.0%)

(2.6%)

(7,4%)

(9,1%)

(4.3%)

(6,8%)

(8,2%)

(3.7%)

(9,3%)

(13,3%)

(6,7%)

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