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Table 7 Multivariate stepwise binary logistic regression analysis between CCC and ASY including as covariates the gender and the polymorphisms associated in univariate analysis gene by gene

From: Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways

GENE: CCR5   
Step Covariates Groups Association test
Step1 gender Male vs Female p = 0.002; OR = 2.042; 95% CI: 1.31-3.19
  rs3176763 CC vs CA + AA p = 0.014; OR = 1.689; 95% CI: 1.11-2.57
  rs11575815 AA + AT vs TT p = 0.077; OR = 1.328; 95% CI: 1.03-1.82
Step2 gender Male vs Female p = 0.001; OR = 2.058; 95% CI: 1.32-3.21
  rs3176763 CC vs CA + AA p = 0.007; OR = 1.766; 95% CI: 1.16-2.68
  rs11575815 AA + AT vs TT Excluded
GENE: CCL2   
Step Covariates Groups Association test
Step1 gender Male vs Female p = 0.002; OR = 2.056; 95% CI: 1.31-3.23
  rs2530797 AA vs AG + GG p = 0.162; OR = 1.198; 95% CI: 1.07-1.54
  rs4586 TT vs TC + CC p = 0.348; OR = 1.138; 95% CI: 1.15-1.49
  rs3917891 CC vs CT + TT p = 0.131; OR = 1.392; 95% CI: 1.1-2.140
Step2 gender Male vs Female p = 0.002; OR = 2.070; 95% CI: 1.32-3.25
  rs2530797 AA vs AG + GG p = 0.051; OR = 1.258; 95% CI: 1.00-1.59
  rs3917891 CC vs CT + TT p = 0.095; OR = 1.435; 95% CI: 1.06-2.19
  rs4586 TT vs TC + CC Excluded
Step3 gender Male vs Female p = 0.001; OR = 2.091; 95% CI: 1.33-3.28
  rs2530797 AA vs AG + GG p = 0.022; OR = 1.303; 95% CI: 1.04-1.64
  rs4586 TT vs TC + CC Excluded
  rs3917891 CC vs CT + TT Excluded
GENE: TIRAP   
Step Covariates Groups Association test
Step1 gender Male vs Female p = 0.002; OR = 2.062; 95% CI: 1.30-3.27
  rs8177376 AA vs AC + CC p = 0.013; OR = 1.357; 95% CI: 1.06-1.73
  rs17866704 TT vs TC + CC p = 0.039; OR = 1.298; 95% CI: 1.01-1.66