Table 7 Multivariate stepwise binary logistic regression analysis between CCC and ASY including as covariates the gender and the polymorphisms associated in univariate analysis gene by gene

Step1

gender

Male vs Female

p = 0.002; OR = 2.042; 95% CI: 1.31-3.19

rs3176763

CC vs CA + AA

p = 0.014; OR = 1.689; 95% CI: 1.11-2.57

rs11575815

AA + AT vs TT

p = 0.077; OR = 1.328; 95% CI: 1.03-1.82

Step2

gender

Male vs Female

p = 0.001; OR = 2.058; 95% CI: 1.32-3.21

rs3176763

CC vs CA + AA

p = 0.007; OR = 1.766; 95% CI: 1.16-2.68

rs11575815

AA + AT vs TT

Excluded

GENE:

CCL2

Step

Covariates

Groups

Association test

Step1

gender

Male vs Female

p = 0.002; OR = 2.056; 95% CI: 1.31-3.23

rs2530797

AA vs AG + GG

p = 0.162; OR = 1.198; 95% CI: 1.07-1.54

rs4586

TT vs TC + CC

p = 0.348; OR = 1.138; 95% CI: 1.15-1.49

rs3917891

CC vs CT + TT

p = 0.131; OR = 1.392; 95% CI: 1.1-2.140

Step2

gender

Male vs Female

p = 0.002; OR = 2.070; 95% CI: 1.32-3.25

rs2530797

AA vs AG + GG

p = 0.051; OR = 1.258; 95% CI: 1.00-1.59

rs3917891

CC vs CT + TT

p = 0.095; OR = 1.435; 95% CI: 1.06-2.19

rs4586

TT vs TC + CC

Excluded

Step3

gender

Male vs Female

p = 0.001; OR = 2.091; 95% CI: 1.33-3.28

rs2530797

AA vs AG + GG

p = 0.022; OR = 1.303; 95% CI: 1.04-1.64

rs4586

TT vs TC + CC

Excluded

rs3917891

CC vs CT + TT

Excluded

GENE:

TIRAP

Step

Covariates

Groups

Association test

Step1

gender

Male vs Female

p = 0.002; OR = 2.062; 95% CI: 1.30-3.27

rs8177376

AA vs AC + CC

p = 0.013; OR = 1.357; 95% CI: 1.06-1.73

rs17866704

TT vs TC + CC

p = 0.039; OR = 1.298; 95% CI: 1.01-1.66