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Table 3 Association studies performed on an independent cohort including as covariates the gender and the polymorphism one by one

From: Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways

CCC VS ASY

GENE

Tag SNP

Genotype groups

Association test

CCL2

rs3760396

GG vs GA + AA

p = 0.626; OR = 1.35; 95% CI: 0.40-4.55

 

rs2857656

CC vs CG + GG

p = 0.267; OR = 1.16; 95% CI: 0.89-1.51

 

rs4586

TT vs TC + CC

p = 0.128; OR = 1.25; 95% CI: 1.94-1.67

 

rs3917891

CC vs CT + TT

p = 0.127; OR = 1.42; 95% CI: 0.90-2.23

 

rs2530797

AA vs AG + GG

p = 0.007; OR = 1.46; 95% CI: 1.11-1.92

 

rs991804

CC vs CT + TT

p = 0.435; OR = 1.23; 95% CI: 0.73-2.09

TIRAP

rs11220437

TT vs TC + CC

p = 0.149; OR = 1.27; 95% CI: 0.92-1.75

 

rs591163

GG + GA vs AA

p = 0.154; OR = 1.32; 95% CI: 0.90-1.94

 

rs8177352

AA vs AG + GG

p = 0.278; OR = 1.20; 95% CI: 0.87-1.66

 

rs8177375

AA vs AG + GG

p = 0.256; OR = 1.22; 95% CI: 0.87-1.72

 

rs8177376

AA vs AC + CC

p = 0.037; OR = 1.36; 95% CI: 1.19-1.80

 

rs17866704

TT vs TC + CC

p = 0.051; OR = 1.32; 95% CI: 1.00-1.76

CCC with a left ventricular ejection fraction value under 0.4% VS ASY

GENE

Tag SNP

Genotype groups

Association test

CCL2

rs3760396

GG vs GA + AA

p = 0.392; OR = 1.84; 95% CI: 0.45-7.46

 

rs2857656

CC vs CG + GG

p = 0.499; OR = 1.10; 95% CI: 0.83-1.46

 

rs4586

TT vs TC + CC

p = 0.194; OR = 1.23; 95% CI: 0.90-1.67

 

rs3917891

CC vs CT + TT

p = 0.156; OR = 1.40; 95% CI: 0.88-2.24

 

rs2530797

AA vs AG + GG

p = 0.002; OR = 1.59; 95% CI: 1.19-2.13

 

rs991804

CC vs CT + TT

p = 0.876; OR = 1.05; 95% CI: 0.60-1.83

TIRAP

rs11220437

TT vs TC + CC

p = 0.265; OR = 1.21; 95% CI: 0.86-1.71

 

rs591163

GG + GA vs AA

p = 0.134; OR = 1.38; 95% CI: 0.91-2.10

 

rs8177352

AA vs AG + GG

p = 0.224; OR = 1.23; 95% CI: 0.88-1.73

 

rs8177375

AA vs AG + GG

p = 0.313; OR = 1.21; 95% CI: 0.84-1.74

 

rs8177376

AA vs AC + CC

p = 0.046; OR = 1.36; 95% CI: 1.05-1.85

 

rs17866704

TT vs TC + CC

p = 0.095; OR = 1.29; 95% CI: 0.96-1.74