Constrictive pleuropericarditis: a dominant clinical manifestation in Whipple’s disease

BMC Infectious Diseases

Table 1 Previously reported cases of constrictive pericarditis in Whipple’s disease

Study	Age at Diagnosis, Sex	Prodromal symptoms	Delay between prodromal stage and pericardial involvement	Pericardial histologic results	GI Histologic results	Pleural effusions	Treatment	Outcome
Vlietstra RE et al. [12]	63, male	Arthralgia, Weight loss	8 years	PAS + histiocytes, electron microscopy+	Duodenal: PAS+, electron microscopy+	N/A	Tetracycline, pericardiectomy
Crake et al. [7]	37, male	Chest pain, shortness of breath	0	PAS + macropages	Duodenal: PAS+	N/A	Pericardiectomy, tetracycline	Survived
Freychet et al. [11]	61, male	Arthralgia, diarrhea	Not specified	PAS + macrophages; electron microscopy +	Jejunal: negative	Unilateral	N/A	N/A
Iqbal et al. [8]	58, male	Orthopnea, lymphadenopathy, ascites	0	PAS + macrophages; electron microscopy +	Jejunal: PAS + histiocytes	Unilateral, transudate	Ceftriaxone, tetracycline, pericardiectomy	Survived
Makol et al. [9]	56, male	Seronegative inflammatory arthritis	20 years	PAS + macrophages; T.whipplei PCR+	Jejunal: negative	Bilateral	Ceftriaxone, Bactrim, pericardiectomy	Survived
Sutherland et al. [10]	45, male	Anemia, weight loss, lymphadenopathy	6 months	N/A	Duodenal: PAS+, electron microscopy+	bilateral	Ceftriaxone, Bactrim, pericardiectomy	Survived

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