|
First line drugsa
|
Second line drugs
|
---|
Household/index contacts
|
INH
|
RIF
|
EMB
|
PZA
|
STR
|
CAP
|
KAN
|
AMI
|
ETH
|
CYC
|
PAS
|
---|
|
0.2
|
1.0
|
1.0
|
7.5
|
300
|
2.0
|
10
|
10
|
6.0
|
6.0
|
10
|
60.0
|
8.0
|
---|
IC1
|
R
|
R
|
R
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
HC1
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
IC2
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
HC2
|
R
|
R
|
R
|
S
|
S
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
IC3
|
R
|
S
|
R
|
S
|
S
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
HC3
|
R
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
IC4
|
R
|
R
|
R
|
S
|
N/Ab
|
R
|
S
|
S
|
S
|
S
|
R
|
S
|
S
|
HC4
|
R
|
R
|
S
|
S
|
S
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
IC5
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
HC5
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
IC6
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
S
|
S
|
S
|
R
|
S
|
S
|
HC6.1
|
R
|
R
|
R
|
R
|
S
|
R
|
R
|
S
|
S
|
S
|
R
|
S
|
S
|
HC6.2
|
R
|
R
|
R
|
R
|
S
|
R
|
R
|
S
|
S
|
S
|
R
|
S
|
S
|
HC6.3
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
IC7
|
R
|
S
|
R
|
R
|
S
|
R
|
R
|
S
|
S
|
S
|
R
|
S
|
S
|
HC7.1
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
HC7.2
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
IC8
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
HC8
|
S
|
S
|
S
|
S
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
IC9
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
HC9
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
IC10
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
HC10
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
IC11
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
HC11
|
R
|
R
|
R
|
S
|
S
|
S
|
S
|
R
|
S
|
S
|
R
|
S
|
S
|
IC12
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
HC12
|
R
|
R
|
R
|
R
|
S
|
R
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
IC13
|
R
|
R
|
R
|
R
|
S
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
HC13
|
R
|
R
|
R
|
R
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
- Susceptibilities are reported in μg/mL.
- Abbreviations: INH – isoniazid, RIF – rifampin, EMB – ethambutol, PZA – pyrazinamide, STR – streptomycin, CAP – capreomycin, KAN – kanamycin, AMI – amikacin, ETH – ethionamide, CYC – cycloserine, PAS – para-aminosalicylic acid; R – resistant, S – susceptible.
-
aWith the exception of PZA, susceptibility for all drugs was performed by the 1% indirect agar proportion method. PZA susceptibility was performed on the VersaTREK (TREK Diagnostics, Cleveland, OH).
-
bIsolate unable to grow in test medium for PZA susceptibility testing.