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Table 2 Drug susceptibilities of Mycobacterium tuberculosis isolates from index case (IC) and household contact (HC) cases in the Philippines

From: Genotypic characteristics of Mycobacterium tuberculosis isolated from household contacts of tuberculosis patients in the Philippines

  First line drugsa Second line drugs
Household/index contacts INH RIF EMB PZA STR CAP KAN AMI ETH CYC PAS
  0.2 1.0 1.0 7.5 300 2.0 10 10 6.0 6.0 10 60.0 8.0
IC1 R R R R R S S S S S S S S
HC1 R R S S S S S S S S S S S
IC2 R R R R R R R S S S S S S
HC2 R R R S S R R S S S S S S
IC3 R S R S S R R S S S S S S
HC3 R R R S S S S S S S S S S
IC4 R R R S N/Ab R S S S S R S S
HC4 R R S S S R S S S S S S S
IC5 R R R R R R R S S S S S S
HC5 R R R R R R R S S S S S S
IC6 R R R R R R R S S S R S S
HC6.1 R R R R S R R S S S R S S
HC6.2 R R R R S R R S S S R S S
HC6.3 S S S S S S S S S S S S S
IC7 R S R R S R R S S S R S S
HC7.1 S S S S S S S S S S S S S
HC7.2 S S S S S S S S S S S S S
IC8 R S S S S S S S S S S S S
HC8 S S S S R S S S S S S S S
IC9 R R R R R R R S S S S S S
HC9 R R R R R R R S S S S S S
IC10 R S S S S S S S S S S S S
HC10 R S S S S S S S S S S S S
IC11 S S S S S S S S S S S S S
HC11 R R R S S S S R S S R S S
IC12 R R R R R R R R S S S S S
HC12 R R R R S R R R S S S S S
IC13 R R R R S R S S S S S S S
HC13 R R R R S S S S S S S S S
  1. Susceptibilities are reported in μg/mL.
  2. Abbreviations: INH – isoniazid, RIF – rifampin, EMB – ethambutol, PZA – pyrazinamide, STR – streptomycin, CAP – capreomycin, KAN – kanamycin, AMI – amikacin, ETH – ethionamide, CYC – cycloserine, PAS – para-aminosalicylic acid; R – resistant, S – susceptible.
  3. aWith the exception of PZA, susceptibility for all drugs was performed by the 1% indirect agar proportion method. PZA susceptibility was performed on the VersaTREK (TREK Diagnostics, Cleveland, OH).
  4. bIsolate unable to grow in test medium for PZA susceptibility testing.