Table 1 IS6110 Restriction fragment length polymorphism (RFLP), spoligotyping, and mycobacterial interspersed repetitive unit variable numbers of tandem repeat (MIRU-VNTR) typing patterns of Mycobacterium tuberculosis isolates from index case (IC) and household contact (HC) cases from the Philippines
Household/index group | RFLP Pattern | Spoligotype pattern | MIRU-VNTR Code | Lineage/family | Methods with matching paired IC-HC | DST match? |
|---|---|---|---|---|---|---|
1 Spacer # 43 | ||||||
IC1 | 5–13 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 244336223432 | Manila | ||
HC1 | 5–13 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 244336223432 | Manila | RFLP/Spoligo/MIRU | No |
IC2 | 10–14 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 254326223432 | Manila | ||
HC2 | 34–13 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 254326223432 | Manila | Spoligo/MIRU | No |
IC3 | 2–13 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ □□□ □□□ □□■ ■■■ ■■■ ■ | 254326223432 | ND | ||
HC3 | 2–13 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ □□□ □□□ □□■ ■■■ ■■■ ■ | 254326223432 | ND | RFLP/Spoligo/MIRU | No |
IC4 | 35–11 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 254326223422 | Manila | ||
HC4 | 3–12 | ■■□ ■■■ ■■■ ■■■ ■□□ □■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 254326223432 | ND | None | No |
IC5 | 1–13 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 254326223332 | Manila | ||
HC5 | 1–13 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 254326223332 | Manila | RFLP/Spoligo/MIRU | Yes |
IC6 | 11–15 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 234326223432 | Manila | ||
HC6.1 | 4–16 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 234326223432 | Manila | Spoligo/MIRU (IC6/HC6.1) | No |
HC6.2 | 6–14 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 234326223432 | Manila | Spoligo/MIRU (IC6/HC6.2) | No |
HC6.3 | 7–13 | □■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □□□ ■■■ ■■■ ■ | 253326223432 | ND | None (IC6/HC6.3) | No |
IC7 | 19–12 | ■■□ ■■■ ■□□ □□□ □□□ □□□ □□□ □□□ □□□ □□□ □□□ □□□ □□■ ■■■ ■ | 254326223432 | ND | ||
HC7.1 | 20–13 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 254326223432 | Manila | MIRU (IC7/HC7.1) | No |
HC7.2 | 18–11 | ■■□ ■■■ □■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □□■ □■■ ■■■ ■ | 274326223432 | ND | None (IC7/HC7.1) | No |
IC8 | 12–15 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 234326223432 | Manila | ||
HC8 | 37–13 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 254326223432 | Manila | Spoligo | No |
IC9 | 14–19 | □□□ □□□ □□□ □□□ □□□ □□□ □□□ □□□ □□□ □□□ □□□ □■■ ■■■ ■■■ ■ | 223325173533 | Beijing | ||
HC9 | 14–19 | □□□ □□□ □□□ □□□ □□□ □□□ □□□ □□□ □□□ □□□ □□□ □■■ ■■■ ■■■ ■ | 223325173533 | Beijing | RFLP/Spoligo/MIRU | Yes |
IC10 | 27–12 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 254326223422 | Manila | ||
HC10 | 27–12 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 254326223422 | Manila | RFLP/Spoligo/MIRU | Yes |
IC11 | 25–15 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ □□□ □□□ □□□ □□□ □□□ □□□ □ | 254326224332 | ND | ||
HC11 | 23–12 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 254326223432 | ND | MIRU | No |
IC12 | 32–11 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■■□ □□□ □□□ □□□ ■■□ □□□ ■■■ ■■■ ■ | 224227163221 | ND | ||
HC12 | 28–13 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■■□ □□□ □□□ □□□ ■■□ □□□ ■■■ ■■■ ■ | 224227163321 | ND | Spoligo/MIRU | No |
IC13 | 29–11 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 354326223422 | Manila | ||
HC13 | 29–11 | ■■□ ■■■ ■■■ ■■■ ■■■ ■■■ ■□□ ■■■ ■■■ ■□□ □□■ □■■ ■■■ ■■■ ■ | 354326223422 | Manila | RFLP/Spoligo/MIRU | No |