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Table 3 Input variables and distribution for Monte Carlo simulation sensitivity analyses

From: Pharmacoeconomic evaluation of voriconazole vs. liposomal amphotericin B in empiric treatment of invasive fungal infections in Turkey

Input variable

Voriconazole

LAmB

Fever without baseline infection

Triangular distribution, 92.03%-96.87%-100%

Triangular distribution, 93.65%-98.58%-100%

  Therapeutic success

Triangular distribution, 24.10%-25.37%-26.64%

Triangular distribution, 28.55%-30.05%-31.55%

  Therapeutic failure

Triangular distribution, 70.90%-74.63%-78.36%

Triangular distribution, 66.45%-69.95%-73.45%

    Death

Triangular distribution, 10.45%-11.00%-11.55%

Triangular distribution, 8.16%-8.59%-9.02%

    Breakthrough infection

Triangular distribution, 2.40%-2.67%-2.94%

Triangular distribution, 6.50%-7.22%-7.94%

    Premature discontinuation

Triangular distribution, 12.30%-13.67%-15.04%

Triangular distribution, 8.66%-9.62%-10.58%

    Persistent fever

Triangular distribution, 65.40%-72.67%-79.94%

Triangular distribution, 67.11%-74.57%-82.03%

Fever with baseline infection

Triangular distribution, 2.97%-3.13%-3.29%

Triangular distribution, 1.20%-1.42%-1.49%

  Therapeutic success

Triangular distribution, 43.84%-46.15%-48.46%

Triangular distribution, 63.34%-66.67%-70.00%

  Therapeutic failure

Triangular distribution, 51.16%-53.85%-56.54%

Triangular distribution, 31.66%-33.33%-35.00%

Ward “per diem”

Discrete, 30% at TL193.40 and 70% at TL30.00

ICU length of stay

Log-normal, mean 5 days, standard deviation 2.5 days

Overall treatment duration

Log-normal, mean 10 days, standard deviation 2 days

Proportion of oral voriconazole use

Triangular distribution, 0-22-50%