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Table 3 Input variables and distribution for Monte Carlo simulation sensitivity analyses

From: Pharmacoeconomic evaluation of voriconazole vs. liposomal amphotericin B in empiric treatment of invasive fungal infections in Turkey

Input variable Voriconazole LAmB
Fever without baseline infection Triangular distribution, 92.03%-96.87%-100% Triangular distribution, 93.65%-98.58%-100%
  Therapeutic success Triangular distribution, 24.10%-25.37%-26.64% Triangular distribution, 28.55%-30.05%-31.55%
  Therapeutic failure Triangular distribution, 70.90%-74.63%-78.36% Triangular distribution, 66.45%-69.95%-73.45%
    Death Triangular distribution, 10.45%-11.00%-11.55% Triangular distribution, 8.16%-8.59%-9.02%
    Breakthrough infection Triangular distribution, 2.40%-2.67%-2.94% Triangular distribution, 6.50%-7.22%-7.94%
    Premature discontinuation Triangular distribution, 12.30%-13.67%-15.04% Triangular distribution, 8.66%-9.62%-10.58%
    Persistent fever Triangular distribution, 65.40%-72.67%-79.94% Triangular distribution, 67.11%-74.57%-82.03%
Fever with baseline infection Triangular distribution, 2.97%-3.13%-3.29% Triangular distribution, 1.20%-1.42%-1.49%
  Therapeutic success Triangular distribution, 43.84%-46.15%-48.46% Triangular distribution, 63.34%-66.67%-70.00%
  Therapeutic failure Triangular distribution, 51.16%-53.85%-56.54% Triangular distribution, 31.66%-33.33%-35.00%
Ward “per diem” Discrete, 30% at TL193.40 and 70% at TL30.00
ICU length of stay Log-normal, mean 5 days, standard deviation 2.5 days
Overall treatment duration Log-normal, mean 10 days, standard deviation 2 days
Proportion of oral voriconazole use Triangular distribution, 0-22-50%