Fever without baseline infection

Triangular distribution, 92.03%96.87%100%

Triangular distribution, 93.65%98.58%100%

Therapeutic success

Triangular distribution, 24.10%25.37%26.64%

Triangular distribution, 28.55%30.05%31.55%

Therapeutic failure

Triangular distribution, 70.90%74.63%78.36%

Triangular distribution, 66.45%69.95%73.45%

Death

Triangular distribution, 10.45%11.00%11.55%

Triangular distribution, 8.16%8.59%9.02%

Breakthrough infection

Triangular distribution, 2.40%2.67%2.94%

Triangular distribution, 6.50%7.22%7.94%

Premature discontinuation

Triangular distribution, 12.30%13.67%15.04%

Triangular distribution, 8.66%9.62%10.58%

Persistent fever

Triangular distribution, 65.40%72.67%79.94%

Triangular distribution, 67.11%74.57%82.03%

Fever with baseline infection

Triangular distribution, 2.97%3.13%3.29%

Triangular distribution, 1.20%1.42%1.49%

Therapeutic success

Triangular distribution, 43.84%46.15%48.46%

Triangular distribution, 63.34%66.67%70.00%

Therapeutic failure

Triangular distribution, 51.16%53.85%56.54%

Triangular distribution, 31.66%33.33%35.00%

Ward “per diem”

Discrete, 30% at TL193.40 and 70% at TL30.00

ICU length of stay

Lognormal, mean 5 days, standard deviation 2.5 days

Overall treatment duration

Lognormal, mean 10 days, standard deviation 2 days

Proportion of oral voriconazole use

Triangular distribution, 02250%
