Variable | No. of studies | No. of cases/controls | OR (95% CI) | P value | I2 | Phet a | PB-D test b |
---|---|---|---|---|---|---|---|
For oipA on/off studies | |||||||
PUD vs. gastritis/FD | |||||||
All | 10 | 439/583 | 3.97 (2.89,5.45) | <0.001 | 22.30% | 0.238 | |
Region | 0.681 | ||||||
Europe | 7 | 250/285 | 3.75 (2.54,5.53) | <0.001 | 57.20% | 0.029 | |
Asia | 2 | 28/138 | 2.42 (0.61,9.55) | 0.208 | 32.90% | 0.222 | |
America | 4 | 161/160 | 4.77 (2.65,8.56) | <0.001 | 0.00% | 0.902 | |
Detection technique | 0.376 | ||||||
PCR based-sequencing | 11 | 359/503 | 3.83 (2.71,5.40) | <0.001 | 41.10% | 0.075 | |
Immunoblot | 2 | 80/80 | 4.42 (1.98,9.83) | <0.001 | 0.00% | 0.492 | |
Age | 0.014 | ||||||
Adult | 11 | 351/470 | 3.26 (2.26,4.69) | <0.001 | 16.90% | 0.282 | |
Children | 2 | 88/113 | 7.03 (3.71,13.34) | <0.001 | 0.00% | 0.319 | |
GU vs. gastritis/FD | 2 | 33/115 | 2.85 (0.94,8.69) | 0.065 | 0.00% | 0.368 | |
DU vs. gastritis/FD | 6 | 205/241 | 3.83 2.32,6.34) | <0.001 | 0.00% | 0.628 | |
GC vs. gastritis/FD | |||||||
All | 5 | 144/287 | 2.43 (1.45,4.07) | 0.001 | 16.80% | 0.308 | |
Region | 0.697 | ||||||
Europe | 1 | 9/29 | 4.89 (0.54,44.57) | 0.159 | / | / | |
Asia | 2 | 24/138 | 1.08 (0.29,3.99) | 0.909 | 0.00% | 0.796 | |
America | 3 | 111/120 | 2.47 (1.36,4.51) | 0.003 | 51.30% | 0.128 | |
Detection technique | 0.034 | ||||||
PCR based-sequencing | 5 | 104/247 | 1.75 (0.96,3.18) | 0.066 | 0.00% | 0.634 | |
Immunoblot | 1 | 40/40 | 6.00 (1.79,20.15) | 0.004 | / | / | |
For oipA presence/absence studies | |||||||
PUD vs. gastritis/FD | |||||||
All | 7 | 267/486 | 1.93 (0.60,6.25) | 0.278 | 85.70% | <0.001 | |
Region | <0.001 | ||||||
Asia | 8 | 189/291 | 2.64 (0.85,8.20) | 0.092 | 76.40% | <0.001 | |
Africa | 1 | 78/195 | 0.20 (0.08,0.49) | <0.001 | / | / | |
GU vs. gastritis/FD | 3 | 93/139 | 3.55 (0.71,17.77) | 0.123 | 76.00% | 0.016 | |
DU vs. gastritis/FD | 2 | 60/91 | 3.15 (0.28,35.66) | 0.354 | 87.10% | 0.005 | |
GC vs. gastritis/FD | 4 | 101/215 | 2.09 (0.51,8.66) | 0.308 | 79.10% | 0.002 |