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Table 2 Meta-analysis results for association between oipA on/off and presence/absence status and PUD and GC

From: Association of presence/absence and on/off patterns of Helicobacter pylori oipA gene with peptic ulcer disease and gastric cancer risks: a meta-analysis

Variable No. of studies No. of cases/controls OR (95% CI) P value I2 Phet a PB-D test b
For oipA on/off studies
PUD vs. gastritis/FD
All 10 439/583 3.97 (2.89,5.45) <0.001 22.30% 0.238  
Region        0.681
Europe 7 250/285 3.75 (2.54,5.53) <0.001 57.20% 0.029  
Asia 2 28/138 2.42 (0.61,9.55) 0.208 32.90% 0.222  
America 4 161/160 4.77 (2.65,8.56) <0.001 0.00% 0.902  
Detection technique        0.376
PCR based-sequencing 11 359/503 3.83 (2.71,5.40) <0.001 41.10% 0.075  
Immunoblot 2 80/80 4.42 (1.98,9.83) <0.001 0.00% 0.492  
Age        0.014
Adult 11 351/470 3.26 (2.26,4.69) <0.001 16.90% 0.282  
Children 2 88/113 7.03 (3.71,13.34) <0.001 0.00% 0.319  
GU vs. gastritis/FD 2 33/115 2.85 (0.94,8.69) 0.065 0.00% 0.368  
DU vs. gastritis/FD 6 205/241 3.83 2.32,6.34) <0.001 0.00% 0.628  
GC vs. gastritis/FD
All 5 144/287 2.43 (1.45,4.07) 0.001 16.80% 0.308  
Region        0.697
Europe 1 9/29 4.89 (0.54,44.57) 0.159 / /  
Asia 2 24/138 1.08 (0.29,3.99) 0.909 0.00% 0.796  
America 3 111/120 2.47 (1.36,4.51) 0.003 51.30% 0.128  
Detection technique        0.034
PCR based-sequencing 5 104/247 1.75 (0.96,3.18) 0.066 0.00% 0.634  
Immunoblot 1 40/40 6.00 (1.79,20.15) 0.004 / /  
For oipA presence/absence studies
PUD vs. gastritis/FD
All 7 267/486 1.93 (0.60,6.25) 0.278 85.70% <0.001  
Region        <0.001
Asia 8 189/291 2.64 (0.85,8.20) 0.092 76.40% <0.001  
Africa 1 78/195 0.20 (0.08,0.49) <0.001 / /  
GU vs. gastritis/FD 3 93/139 3.55 (0.71,17.77) 0.123 76.00% 0.016  
DU vs. gastritis/FD 2 60/91 3.15 (0.28,35.66) 0.354 87.10% 0.005  
GC vs. gastritis/FD 4 101/215 2.09 (0.51,8.66) 0.308 79.10% 0.002  
  1. The statistically significant results were highlighted in bold.
  2. a, P value for heterogeneity test; b, P value for Breslow-Day test.
  3. Abbreviations: FD functional dyspepsia, PUD peptic ulcer disease, GU gastric ulcer, DU duodenal ulcer, GC gastric cancer.