Effects of a combination of amlodipine and imipenem on 42 clinical isolates of Acinetobacter baumannii obtained from a teaching hospital in Guangzhou, China

Table 4 Imipenem potency in the absence and presence of AML in 42 A. baumannii isolates

Compound/combination of compounds	MIC (μg/ml)			No. susceptible (%)	No. nonsusceptible (%)^a	Statistical analysis^b
Compound/combination of compounds	MIC_Range	MIC₅₀	MIC₉₀	No. susceptible (%)	No. nonsusceptible (%)^a	χ²-values	P values
AML	40-320	80	160	-	-	-	-
IPM	0.5-32	16	16	7 (16.7%)	35 (83.3%)	-	-
IPM +10 μg/ml AML	0.5-32	8	16	13 (31.0%)	29 (69.0%)	2.363	0.200
IPM +20 μg/ml AML	0.5-32	8	16	15 (35.7%)	27 (64.3%)	3.941	0.081
IPM +40 μg/ml AML	<0.5-32	4	16	23 (54.8%)	19 (45.2%)	13.274	0.001

MIC, minimum inhibitory concentration; MIC₅₀ and MIC₉₀, MICs for 50% and 90% of strains, respectively; ^anonsusceptible, including intermediate resistance; ^bstatistical analysis compared with the IPM group.

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