|  | Cohort 1 |  |  | Cohort 2 |  |  | RCT arms |  |  |
---|---|---|---|---|---|---|---|---|---|---|
Predictor | Anaemia failures/n | Unadjusted hazard ratio (HR) | Adjusted HR | P-valueii | Unadjusted HR | Adjusted HR | P-valueii | Unadjusted HR | Adjusted HR | P-valueii |
 |  | (95% CI) | (95% CI) i |  | (95% CI) | (95% CI) i |  | (95% CI) | (95% CI) i |  |
Observational cohort | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Cohort 1: ART (CD4 < 200) | 52/118 | --- | --- | --- | --- | --- | --- | --- | --- | --- |
Cohort 2: ZDV plus sdNVP (CD4 > 500) | 15/128 | --- | --- | --- | --- | --- | --- | --- | --- | --- |
Intervention armiii | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
RCT arm A: Triple ARV (CD4 200–500)iv/v | 97/412 | --- | --- | --- | --- | --- | --- | 1 | 1 | --- |
RCT arm B: ZDV plus sdNVP (CD4 200–500)iv/v | 84/412 | --- | --- | --- | --- | --- | --- | 1.09 (0.77,1.52) | 0.78 (0.54,1.11) | 0.166 |
Country | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Burkina Faso | 70/345 | 1 | 1 | --- | 1 | --- | --- | 1 | 1 | --- |
Kenya | 157/441 | 1.66 (0.88,3.13) | 1.56 (0.80,3.07) | 0.192 | 1.11 (0.41,3.02) | --- | --- | 2.70 (1.76,4.13) | 2.76 (1.79,4.25) | <0.001 |
South Africa | 21/281 | --- | --- | --- | --- | --- | --- | 0.42 (0.23,0.75) | 0.52 (0.26,1.01) | 0.054 |
Age (enrolment) | 248/1070 | 0.95 (0.88,1.02) | 0.96 (0.89,1.04) | 0.312 | 0.95 (0.82,1.11) | --- | --- | 1.00 (0.97,1.04) | --- | --- |
BMI (enrolment) | 248/1070 | 1.02 (0.93,1.11) | --- | --- | 0.97 (0.87,1.09) | --- | --- | 0.96 (0.92,1.01) | 1.00 (0.95,1.05) | 0.964 |
Secondary or higher education versus none or primary level (enrolment) | 90/511 | Â | --- | --- | Â | --- | --- | 0.57 (0.40,0.81) | 0.85 (0.56,1.26) | 0.413 |
HIV stage 3 vi versus stage 1 or 2 (enrolment) | 48/101 | 1.31 (0.71,2.44) | --- | --- | Insufficient observations | --- | --- | 2.11 (1.18,3.79) | 2.11 (1.19,3.75) | 0.011 |
Most poor SES category versus poor or least poor (enrolment) | 73/209 | 1.44 (0.73,2.85) | --- | --- | 5.13 (1.83,14.41) | 4.08 (1.54,10.75) | 0.005 | 1.57 (1.06,2.32) | 1.13 (0.75,1.70) | 0.567 |
First pregnancy (enrolment) | 37/185 | 0.90 (0.34,2.41) | --- | --- | 1.35 (0.44,4.19) | --- | --- | 0.88 (0.56,1.40) | --- | --- |
Never breastfed | 69/285 | 1.49 (0.80,2.78) | --- | --- | 0.24 (0.03,1.86) | --- | --- | 1.00 (0.66,1.50) | --- | --- |
Prolonged breastfeeding | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
< 6Â months | 138/640 | 1 | 1 | --- | 1 | 1 | --- | 1 | 1 | --- |
> = 6 months | 31/103 | 0.79 (0.28,2.23) | --- | --- | 0.77 (0.19,3.13) | 1.12 (0.27,4.76) | 0.873 | 1.46 (0.88,2.41) | 1.62 (1.00,2.62) | 0.051 |
0 duration (did not breast-feed) | 69/285 | 1.43 (0.74,2.79) | --- | --- | 0.23 (0.03,1.80) | 0.33 (0.04,2.48) | 0.280 | 1.06 (0.69,1.61) | 1.05 (0.68,1.62) | 0.831 |
Cumulative duration on ARV (in years, continuous scale) | 248/1070 | 0.03 (0.00,0.27) | 0.04 (0.00,0.29) | 0.002 | 0.02 (0.00,vii) | --- | --- | 0.03 (0.00,0.24) | 0.05 (0.01,0.37) | 0.003 |