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Figure 1 | BMC Infectious Diseases

Figure 1

From: Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing

Figure 1

Observed DRMs at all sequenced sampling time-points for each patient. Panel A shows the percentage of DRMs expressed as in each prevalence category for each patient. DRMs observed at less than 1% of the amplified and sequenced viral population were discounted from further analysis in this study to account for potential errors due to the error rate of PCR and UDPS but are shown in this figure for comparison purposes. Panel B shows the prevalence of DRMs present in the amplified and sequenced viral population against the patients’ current therapy at each of the sampling time-points. For each prevalence point, the upper and lower 95% confidence intervals from the binomial sampling distribution are shown as error bars. DRMs with a prevalence less than 1% of the amplified and sequenced viral population are not included.

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