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Table 3 Baseline characteristics, comorbidities and treatment parameters of different multidrug-resistant Pseudomonas aeruginosa

From: Effect of metallo-β-lactamase production and multidrug resistance on clinical outcomes in patients with Pseudomonas aeruginosabloodstream infection: a retrospective cohort study

Parameter

MBL (n = 18)

Non-MBL (n = 95)

P-value

3/4MDR (n = 27)

Non-3/4MDR (n = 86)

P-value

Basic parameters

Age, years*

60 (53-64)

67 (52-74)

0.16

59 (48-64)

68.5 (54-75)

0.01

Male sex (%)

11 (61)

60 (63)

0.87

17 (63)

54 (63)

0.99

Fatal outcome (%)

11 (61)

32 (34)

0.03

17 (63)

26 (30)

0.002

Length of stay, days*

23 (20-45)

15 (8-41)

0.03

23 (13-45)

14.5 (7-41)

0.03

Comorbid conditions

Immune suppression (%)

18 (100)

76 (80)

0.04

27 (100)

67 (78)

0.006

Neutropenia (%)

15 (83)

23 (24)

<0.001

17 (63)

21 (24)

<0.001

Cardiovascular disease (%)

7 (39)

59 (62)

0.07

11 (41)

55 (64)

0.03

Diabetes (%)

5 (28)

32 (34)

0.62

7 (26)

30 (35)

0.39

Pulmonary disease (%)

1 (6)

10 (11)

1

1 (4)

10 (12)

0.46

Neurological disease (%)

2 (11)

22 (23)

0.35

6 (22)

18 (21)

0.89

Renal disease (%)

0 (0)

11 (12)

0.21

1 (4)

10 (12)

0.46

Haematological cancer (%)

17 (94)

19 (20)

<0.001

20 (74)

16 (19)

<0.001

Charlson Comorbidity Score*

2 (2-3)

3 (1-5)

0.86

2 (2-3)

3 (2-5)

0.27

Patients clinical record

SAPS II*

39.5 (36-44)

32 (23-41)

0.002

37 (28-43)

32 (24-41)

0.57

AET (%)

8 (44)

66 (70)

0.04

11 (41)

63 (73)

0.002

ADT (%)

13 (72)

83 (87)

0.14

19 (70)

77 (90)

0.03

  1. *Median (interquartile range).
  2. MBL-PA, metallo-β-lactamase producing Pseudomonas aeruginosa; 3/4MDR-PA, 3/4MDR-Pseudomonas aeruginosa; SAPS II, Simplified Acute Physiology Score II; AET, appropriate empirical treatment; ADT, appropriate definitive treatment.