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Table 5 Combined effect of TLR9 and IFNG SNPs on the development of pulmonary tuberculosis

From: Potential association of pulmonary tuberculosis with genetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinese population

TLR91174 A/G

IFNG2109G/A

PTB patients, n (%)

LTBI controls n (%)

Adjusted OR* (95% CI) p value

Adjusted OR&(95% CI) p value

PTB patients, n (%)

Healthy controls without MTB infection n (%)

Adjusted OR* (95% CI) p value

Adjusted OR&(95% CI)p value

AA/AG

GG/GA

97 (48.5)

122 (61.9)

Ref.

Ref.

97 (48.5)

103 (52.6)

Ref.

Ref.

AA/AG

AA

62 (31.0)

51 (25.9)

1.54 (0.97-2.43) p = 0.065

1.97 (1.12-3.47) p = 0.019

62 (31.0)

60 (30.6)

1.10 (0.70-1.73) p = 0.683

1.02 (0.59-1.77) p = 0.941

G/G

GG/GA

29 (14.5)

18 (9.1)

2.04 (1.07-3.91) p = 0.031

2.17 (0.96-4.91) p = 0.062

29 (14.5)

20 (10.2)

1.55 (0.82-2.94) p = 0.178

1.41 (0.65-3.08) p = 0.399

G/G

A/A

12 (6.0)

6 (3.1)

2.53 (0.92-7.00) p = 0.073

4.31 (0.21-15.31) p = 0.024

12 (6.0)

13 (6.6)

0.98 (0.43-2.25) p = 0.965

0.95 (0.34-2.62) p = 0.918

p for trend

  

0.004

0.002

  

0.433

0.697

  1. Abbreviations: CI confidence interval, LTBI latent M. tuberculosis infection, MTB Mycobacterium tuberculosis, OR odds ratio, PTB pulmonary tuberculosis, SNP single nucleotide polymorphism.
  2. *Partly adjusted for age and gender.
  3. &Fully adjusted for age, gender, education level, income, body mass index, number of BCG vaccination scars and smoking.