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Table 5 Combined effect of TLR9 and IFNG SNPs on the development of pulmonary tuberculosis

From: Potential association of pulmonary tuberculosis with genetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinese population

TLR91174 A/G IFNG2109G/A PTB patients, n (%) LTBI controls n (%) Adjusted OR* (95% CI) p value Adjusted OR&(95% CI) p value PTB patients, n (%) Healthy controls without MTB infection n (%) Adjusted OR* (95% CI) p value Adjusted OR&(95% CI)p value
AA/AG GG/GA 97 (48.5) 122 (61.9) Ref. Ref. 97 (48.5) 103 (52.6) Ref. Ref.
AA/AG AA 62 (31.0) 51 (25.9) 1.54 (0.97-2.43) p = 0.065 1.97 (1.12-3.47) p = 0.019 62 (31.0) 60 (30.6) 1.10 (0.70-1.73) p = 0.683 1.02 (0.59-1.77) p = 0.941
G/G GG/GA 29 (14.5) 18 (9.1) 2.04 (1.07-3.91) p = 0.031 2.17 (0.96-4.91) p = 0.062 29 (14.5) 20 (10.2) 1.55 (0.82-2.94) p = 0.178 1.41 (0.65-3.08) p = 0.399
G/G A/A 12 (6.0) 6 (3.1) 2.53 (0.92-7.00) p = 0.073 4.31 (0.21-15.31) p = 0.024 12 (6.0) 13 (6.6) 0.98 (0.43-2.25) p = 0.965 0.95 (0.34-2.62) p = 0.918
p for trend    0.004 0.002    0.433 0.697
  1. Abbreviations: CI confidence interval, LTBI latent M. tuberculosis infection, MTB Mycobacterium tuberculosis, OR odds ratio, PTB pulmonary tuberculosis, SNP single nucleotide polymorphism.
  2. *Partly adjusted for age and gender.
  3. &Fully adjusted for age, gender, education level, income, body mass index, number of BCG vaccination scars and smoking.