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Table 3 Genotype distribution of the selected SNPs in the study participants (Part 2/2)

From: Potential association of pulmonary tuberculosis with genetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinese population

Selected SNP

Genotype distribution*

p for difference

Gene

SNP (ID)

PTB patients, n (%)

LTBI controls n (%)

Healthy controls without MTB infection n (%)

CCR2

GG

125 (62.5)

125 (63.5)

120 (61.2)

0.397§

190 A/G

GA

62 (31.0)

65 (33.0)

67 (34.2)

0.612&

(rs1799864)

AA

13 (6.5)

7 (3.6)

9 (4.6)

 

CCR5

GG

71 (35.5)

62 (31.5)

59 (30.1)

0.511§

59029 A/G

GA

97 (48.5)

107 (54.3)

102 (52.0)

0.515&

(rs1799987)

AA

32 (16.0)

28 (14.2)

35 (17.9)

 

RANTES

GG

77 (38.5)

63 (32.0)

74 (37.8)

0.349§

-403 G/A

GA

96 (48.0)

101 (51.3)

95 (48.5)

0.988&

(rs2107538)

AA

27 (13.5)

33 (16.8)

27 (13.8)

 

MCP1

GG

71 (35.5)

64 (32.5)

75 (38.3)

0.632§

2518 A/G

GA

96 (48.0)

104 (52.8)

88 (44.9)

0.812&

(rs1024611)

AA

33 (16.5)

29 (14.7)

33 (16.8)

 

NRAMP1

GG

151 (75.5)

151 (76.7)

139 (70.9)

0.837§

D543N

GA

47 (23.5)

43 (21.8)

55 (28.1)

0.582&

(rs17235409)

AA

2 (1.0)

3 (1.5)

2 (1.0)

 

P2X7

AA

116 (58.0)

113 (57.4)

109 (55.6)

0.502§

1513 A/C

AC

76 (38.0)

71 (36.0)

76 (38.8)

0.722&

(rs3751143)

CC

8 (4.0)

13 (6.6)

11 (5.6)

 

P2X7

CC

92 (46.2)

86 (43.7)

86 (43.9)

0.835§

-762 T/C

CT

81 (40.7)

86 (43.7)

88 (44.9)

0.669&

(rs2393799)

TT

26 (13.1)

25 (12.7)

22 (11.2)

 

TNF-α

GG

169 (84.5)

178 (90.4)

176 (89.8)

0.210§

-308 G/A

GA

29 (14.5)

18 (9.1)

19 (9.7)

0.284&

(rs1800629)

AA

=2 (1.0)

1 (0.5)

1 (0.5)

 

IFNG

AA

74 (37.0)

57 (28.9)

73 (37.2)

0.119§

2109 G/A

AG

97 (48.5)

99 (50.3)

85 (43.4)

0.374&

(rs1861494)

GG

29 (14.5)

41 (20.8)

38 (19.4)

 

CD4

CC

188 (94.0)

185 (93.9)

184 (93.9)

0.593§

868 C/T

CT

11 (5.5)

12 (6.1)

12 (6.1)

0.593&

(rs28919570)

TT

1 (0.5)

0

0

 

CD14

TT

54 (27.1)

66 (33.5)

60 (30.6)

0.331§

159 C/T

TC

103 (51.7)

97 (49.2)

104 (53.1)

0.438&

(rs2569190)

CC

42 (21.1)

34 (17.3)

32 (16.3)

 

MBL

CC

150 (75.0)

150 (76.1)

141 (71.9)

0.964§

-221 G/C

CG

48 (24.0)

45 (22.8)

52 (26.5)

0.742&

(rs7096206)

GG

2 (1.0)

2 (1.0)

3 (1.5)

 

TIRAP

CC

196 (98.0)

190 (96.5)

188 (96.4)

0.346§

539 C/T

CT

4 (2.0)

7 (3.6)

7 (3.6)

0.359&

(rs8177374)

TT

0

0

0

 

NFKBIA

AA

150 (75.0)

148 (75.1)

153 (78.1)

0.999§

-881 A/G

AC

48 (24.0)

47 (23.8)

43 (21.9)

0.322&

(rs3138053)

CC

2 (1.0)

2 (1.0)

0

 

NFKBIA

CC

149 (74.9)

148 (75.1)

153 (78.1)

0.998§

-826 C/T

CT

48 (24.1)

47 (23.8)

43 (21.9)

0.316&

(rs2233406)

TT

2 (1.0)

2 (1.0)

0

 
  1. Abbreviations: CD cluster of differentiation, CCR chemokine (C-C motif) receptor, IFKBIA NF-kappa-B inhibitor alpha, IFNG Interferon-gamma, MBL mannose binding lectin, MCP monocyte chemotactic protein, NRAMP natural resistance-associated macrophage protein, LTBI latent M. tuberculosis infection, MTB Mycobacterium tuberculosis, PTB pulmonary tuberculosis, RANTES regulated upon activation, normal T-cell expressed, and secreted, SNP single nucleotide polymorphism, TB tuberculosis, TLR Toll-like receptor, TNF Tumor necrosis factor.
  2. *Sum may not always add up to total because of missing data.
  3. §p for difference between PTB patients and LTBI controls.
  4. &p for difference between PTB patients and Healthy controls without MTB infection.
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BMC Infectious Diseases

ISSN: 1471-2334

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