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Table 3 Genotype distribution of the selected SNPs in the study participants (Part 2/2)

From: Potential association of pulmonary tuberculosis with genetic polymorphisms of toll-like receptor 9 and interferon-gamma in a Chinese population

Selected SNP Genotype distribution* p for difference
Gene SNP (ID) PTB patients, n (%) LTBI controls n (%) Healthy controls without MTB infection n (%)
CCR2 GG 125 (62.5) 125 (63.5) 120 (61.2) 0.397§
190 A/G GA 62 (31.0) 65 (33.0) 67 (34.2) 0.612&
(rs1799864) AA 13 (6.5) 7 (3.6) 9 (4.6)  
CCR5 GG 71 (35.5) 62 (31.5) 59 (30.1) 0.511§
59029 A/G GA 97 (48.5) 107 (54.3) 102 (52.0) 0.515&
(rs1799987) AA 32 (16.0) 28 (14.2) 35 (17.9)  
RANTES GG 77 (38.5) 63 (32.0) 74 (37.8) 0.349§
-403 G/A GA 96 (48.0) 101 (51.3) 95 (48.5) 0.988&
(rs2107538) AA 27 (13.5) 33 (16.8) 27 (13.8)  
MCP1 GG 71 (35.5) 64 (32.5) 75 (38.3) 0.632§
2518 A/G GA 96 (48.0) 104 (52.8) 88 (44.9) 0.812&
(rs1024611) AA 33 (16.5) 29 (14.7) 33 (16.8)  
NRAMP1 GG 151 (75.5) 151 (76.7) 139 (70.9) 0.837§
D543N GA 47 (23.5) 43 (21.8) 55 (28.1) 0.582&
(rs17235409) AA 2 (1.0) 3 (1.5) 2 (1.0)  
P2X7 AA 116 (58.0) 113 (57.4) 109 (55.6) 0.502§
1513 A/C AC 76 (38.0) 71 (36.0) 76 (38.8) 0.722&
(rs3751143) CC 8 (4.0) 13 (6.6) 11 (5.6)  
P2X7 CC 92 (46.2) 86 (43.7) 86 (43.9) 0.835§
-762 T/C CT 81 (40.7) 86 (43.7) 88 (44.9) 0.669&
(rs2393799) TT 26 (13.1) 25 (12.7) 22 (11.2)  
TNF-α GG 169 (84.5) 178 (90.4) 176 (89.8) 0.210§
-308 G/A GA 29 (14.5) 18 (9.1) 19 (9.7) 0.284&
(rs1800629) AA =2 (1.0) 1 (0.5) 1 (0.5)  
IFNG AA 74 (37.0) 57 (28.9) 73 (37.2) 0.119§
2109 G/A AG 97 (48.5) 99 (50.3) 85 (43.4) 0.374&
(rs1861494) GG 29 (14.5) 41 (20.8) 38 (19.4)  
CD4 CC 188 (94.0) 185 (93.9) 184 (93.9) 0.593§
868 C/T CT 11 (5.5) 12 (6.1) 12 (6.1) 0.593&
(rs28919570) TT 1 (0.5) 0 0  
CD14 TT 54 (27.1) 66 (33.5) 60 (30.6) 0.331§
159 C/T TC 103 (51.7) 97 (49.2) 104 (53.1) 0.438&
(rs2569190) CC 42 (21.1) 34 (17.3) 32 (16.3)  
MBL CC 150 (75.0) 150 (76.1) 141 (71.9) 0.964§
-221 G/C CG 48 (24.0) 45 (22.8) 52 (26.5) 0.742&
(rs7096206) GG 2 (1.0) 2 (1.0) 3 (1.5)  
TIRAP CC 196 (98.0) 190 (96.5) 188 (96.4) 0.346§
539 C/T CT 4 (2.0) 7 (3.6) 7 (3.6) 0.359&
(rs8177374) TT 0 0 0  
NFKBIA AA 150 (75.0) 148 (75.1) 153 (78.1) 0.999§
-881 A/G AC 48 (24.0) 47 (23.8) 43 (21.9) 0.322&
(rs3138053) CC 2 (1.0) 2 (1.0) 0  
NFKBIA CC 149 (74.9) 148 (75.1) 153 (78.1) 0.998§
-826 C/T CT 48 (24.1) 47 (23.8) 43 (21.9) 0.316&
(rs2233406) TT 2 (1.0) 2 (1.0) 0  
  1. Abbreviations: CD cluster of differentiation, CCR chemokine (C-C motif) receptor, IFKBIA NF-kappa-B inhibitor alpha, IFNG Interferon-gamma, MBL mannose binding lectin, MCP monocyte chemotactic protein, NRAMP natural resistance-associated macrophage protein, LTBI latent M. tuberculosis infection, MTB Mycobacterium tuberculosis, PTB pulmonary tuberculosis, RANTES regulated upon activation, normal T-cell expressed, and secreted, SNP single nucleotide polymorphism, TB tuberculosis, TLR Toll-like receptor, TNF Tumor necrosis factor.
  2. *Sum may not always add up to total because of missing data.
  3. §p for difference between PTB patients and LTBI controls.
  4. &p for difference between PTB patients and Healthy controls without MTB infection.