Skip to main content

Table 1 Key characteristics of the meta-analyzed reports (n = 24)

From: Meta-analysis to compare the accuracy of GeneXpert, MODS and the WHO 2007 algorithm for diagnosis of smear-negative pulmonary tuberculosis

Test Author, (Year) Ref Country Study HIV rate Specimen type Screen test TP FP FN TN
GeneXpert Helb, 2010 [24] Vietnam 1 Sputum frozen Unclear 38 0 15 25
  Malbruny, 2011 [25] France 3.4 Various FM 6 0 0 73
  Bowles, 2011 [26] Netherlands NR Sputum ZN 21 0 4 23
  Moure, 2011 [27] Spain NR Sputum frozen FM + ZN 61 0 17 20
  Marlowe, 2011 [28] USA NR Sputum sediment Unclear 43 0 12 47
  Theron, 2011 [29] S. Africa 27 Sputum FM 22 19 25 319
  Rachow, 2011 [30] Tanzania 59.9 Sputum frozen ZN 11 1 7 102
  Scott, 2011 [31] S. Africa 70* Sputum sediment FM 11 3 7 104
  Lawn, 2011 [32] S. Africa 100 Sputum FM 23 2 30 320
  Ioannidis, 2011 [33] Greece NR Sputum Unclear 29 2 3 32
  Miller, 2011 [34] USA NR Sputum frozen FM 3 2 2 58
  Teo, 2011 [35] Singapore NR Various ZN 13 2 6 42
  Nicol, 2011 [36] S. Africa 24 Sputum-induced FM 25 0 18 166
  Rachow, 2012 [37] Tanzania 51.2 Sputum ZN 14 0 7 22
  Safianowska, 2012 [38] Poland NR Various ZN 4 0 4 181
  Total       324 31 157 1534
MODS Arias, 2007 [39] Brazil / Honduras 12* Various ZN 75 28 8 469
  Mashta, 2011 [40] India NR Sputum ZN 17 45 27 146
  Shah, 2011 [41] S. Africa 87 Sputum Unclear 36 13 14 407
  Ha DT, 2010 [42] Vietnam 100 Sputum ZN 40 0 15 67
  Chaiyasirinroje, 2012 [43] Thailand NR Sputum Unclear 13 1 4 37
  Total       181 87 68 1126
WHO 2007 algorithm Wilson, 2011 [44] S. Africa 57* Sputum-induced FM 47 91 12 71
  Swai, 2011 [45] Tanzania 68.1 Sputum ZN 66 107 61 179
  Koole, 2012 [46] Cambodia 26.5 Sputum FM 20 70 14 270
  Alamo, 2012. Rural site [8] Uganda 100 Sputum ZN 18 2 1 1
  Alamo, 2012. Urban site [8] Uganda 100 Sputum ZN 9 13 1 10
  Total       160 283 89 531
  1. Specimen type various included = bronchial aspirate, bronchial alveolar lavage.
  2. ZN = Ziehl-Nielsen microscopy stain method.
  3. FM = Fluorescent microscopy stain method.
  4. TP = True positive (Individuals have disease and have positive test).
  5. FP = False positive (Individuals do not have disease, but have positive test).
  6. FN = False negative (Individuals have disease, but have negative test).
  7. TN = True negative (Individuals do not have disease and have negative test).
  8. NR = Not reported.
  9. * = The rate reported was based on a denominator that included patients with undocumented HIV result.