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Table 1 Descriptive baseline characteristics of patients with enterococcal bloodstream infections

From: Impact of vancomycin resistance on mortality in neutropenic patients with enterococcal bloodstream infection: a retrospective study

 

VSE BSI (n=67)

VRE BSI (n=24)

p-value

Age, years

48.0±14.0

44.9±14.5

0.356

Male sex

41 (61.2)

10 (41.7)

0.098

Underlying hematologic diseases

  

0.046

  AML

41 (61.2)

10 (41.7)

0.098

  ALL

18 (26.9)

13 (54.2)

0.015

  Othersa

8 (11.9)

1 (4.2)

0.436

Treatment for underlying diseases

  

0.861

  Chemotherapy

56 (83.6)

20 (83.3)

>0.999

  Allogeneic SCT

9 (13.4)

4 (16.7)

0.738

  Autologous SCT

2 (3.0)

0 (0)

>0.999

Enterococcal species

  

<0.001

  E. faecium

44 (65.7)

22 (91.7)

0.016

  E. faecalis

23 (34.3)

0 (0.0)

<0.001

  E. gallinarum

0 (0.0)

2 (8.3)

0.067

SAPS II at the onset of BSI

39 (28–95)

41 (31–74)

0.336

Charlson’s comorbidity index

2 (0–4)

2 (0–4)

0.644

ICU care

16 (23.9)

7 (29.2)

0.609

Septic shock

8 (11.9)

2 (8.3)

>0.999

Length of hospitalization, day

22 (13–44)

26 (17–77)

0.025

Duration of neutropenia before BSI, day

14 (0–156)

15 (6–27)

0.908

Severity of neutropenia

  

0.112

  ANC <500/mm3

2 (3.0)

3 (12.5)

 

  ANC <100/mm3

65 (97.0)

21 (87.5)

 

Administration of adequate antibiotics

  

0.002

  ≤48 hours after febrile episode

50 (75.8)

10 (41.7)

 

  >48 hours after febrile episode

16 (24.2)

14 (58.3)

 
  1. Data are presented as n (%), mean±SD or median (range). Abbreviations: ALL acute lymphoblastic leukemia, AML acute myeloid leukemia, ANC absolute neutrophil count, BSI bloodstream infection, ICU intensive care unit, SAPS II Simplified Acute Physiology Score, SCT stem cell transplantation, VRE, vancomycin-resistant enterococci, VSE vancomycin-susceptible enterococci. aMyelodysplastic syndrome (n=2), multiple myeloma (n=1), aplastic anemia (n=3), lymphoma (n=2) and hemophagocytic lymphohistiocytosis (n=1).