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Table 5 Impact of HSV-2 seropositivity on CD4 count a

From: Herpes simplex virus type 2 and HIV disease progression: a systematic review of observational studies

Study Population N HSV2 Ascertainment Outcome: CD4 COUNT (in cells/mm3)
Outcome HSV2 pos HSV2 neg Difference Effectb
Studies in acute HIV seroconverters
Cachay 2008 Male HIV seroconverters, USA 9 HSV2 seroconversion by WB Change in CD4 after vs before HSV-2 sero-conversion over 779 days −44 (range = −82,220) Reference: Before seroconversion p = 0.36
Studies in chronic HIV infection
Crum-Cianflone 2006 USA 271 Serology: Focus Change in CD4 at 1 year −116 +14 −130, p=0.003
221 Change in CD4 at 3 years −227 −85 −142, p = 0.03
Roxby 2011 Postpartum women, Kenya 296 Serology: Focus Rate of change in CD4 over mean 18 months −4.22/month −3.42/month −0.8/month p = 0.57
  1. aCI = confidence interval, IQR = interquartile range, NR = not reported, MSM = men who have sex with men, WB = Western Blot.
  2. bArrows show directions of association with HSV-2; ‘?’ denotes borderline statistical significance or clinically significant differences not meeting statistical significance.