Study | Population | N | HSV2 Ascertainment | Outcome: CD4 COUNT (in cells/mm3) | ||||
---|---|---|---|---|---|---|---|---|
Outcome | HSV2 pos | HSV2 neg | Difference | Effectb | ||||
Studies in acute HIV seroconverters | ||||||||
Cachay 2008 | Male HIV seroconverters, USA | 9 | HSV2 seroconversion by WB | Change in CD4 after vs before HSV-2 sero-conversion over 779 days | −44 (range = −82,220) | Reference: Before seroconversion | p = 0.36 | ↔ |
Studies in chronic HIV infection | ||||||||
Crum-Cianflone 2006 | USA | 271 | Serology: Focus | Change in CD4 at 1 year | −116 | +14 | −130, p=0.003 | ↓ |
221 | Change in CD4 at 3 years | −227 | −85 | −142, p = 0.03 | ↓ | |||
Roxby 2011 | Postpartum women, Kenya | 296 | Serology: Focus | Rate of change in CD4 over mean 18 months | −4.22/month | −3.42/month | −0.8/month p = 0.57 | ↔ |