Cardiopulmonary involvement in Puumala hantavirus infection

BMC Infectious Diseases

Table 2 Significant results in relation to need of oxygen and impaired general condition at follow-up

	Oxygen treatment Yes / No	Impaired condition follow-up Yes / No
Laboratory results
Number of patients	9 / 18	13 / 13
Leukocyte count max (3.5-8.8 10⁹/L)	13.0 (9.1-15.7) / 7.8 (6.3-9.2)**	6.5 (5.6-7.9) / 5.4 (5.0-8.5)
Creatinine max (<105 μmol/L)	276 (186–352) / 143 (111–237)*	69 (59–92) / 68 (53–92)
Albumin min (36–45 g/L)	21 (19–27) / 29 (25–31)**	44 (41–49) / 45 (42–46)
Cardiac biomarkers
NT-proBNP max (<150 ng/L)	8470 (2055–12511) / 860 (237–4024)**	75 (36–300) / 49 (15–108)
hs-cTnT max (<15 ng/L)	16 (8–22) / 6 (0–10)*	6 (0–8) / 0 (0–7)
Echocardiographic results
Number of patients	9 / 17	11 / 10
Heart rate (beats/min)	90 (81–104) / 66 (58–84)*	70 (58–84) / 71 (65–79)
Left ventricle IVRT (%)	11.9 (9.4-15.4) / 9.5 (7.8-10.9)*	9.7 (8.6-11.4) / 10.2 (8.7-12.1)
Systolic pulmonary artery pressure, mmHg	47 (35–47) / 33 (26–39)**	34 (29–39) / 27 (27–32)
Pulmonary vascular resistance (WU)	3.7 (2.8-4.4) / 2.3 (1.8-3.1)*	3.1 (1.9-3.7) / 1.8 (1.5-1.8)*
Pulmonary artery acceleration time (ms)	90 (70–111) / 127 (103–147)*	123 (104–137) / 124 (117–144)
TAPSE (mm)	20 (17–24) / 24 (21–30)*	21 (18–23) / 26 (21–29)
Lung function results
Number of patients	7 / 18	12 / 12
DLCO	53 (38–61) / 70 (62–82)*	74 (68–83) / 90 (84–101)*

DLCO, diffusing capacity of the lung for carbon monoxide; hs-cTnT, high-sensitivity cardiac troponin T; IVRT; isovolemic relaxation time (indexed to R-R interval); max, maximum; min, minimum; NT-proBNP, N-terminal pro-B-type natriuretic peptide; TAPSE, tricuspid annular plane systolic excursion; WU, Wood units.
Results are expressed as median (25^th-75^th percentile). Laboratory reference values (decision level for heart failure or myocardial injury for NT-ProBNP and hs-cTnT respectively) are presented in parenthesis. P-values, determined by Mann–Whitney U test, are expressed as * < 0.05, ** < 0.01.

ISSN: 1471-2334