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Table 4 Concordance between LA and LQ in detecting HR-HPV genotypes

From: Comparison of the performance of carcinogenic HPV typing of the Roche Linear Array and Qiagen LiquiChip® HPV assays

HPV genotype

Roche LA (n)

Qiagen LQ (n)

Kappa* [95% CI]

p-value**

HPV 16

128

131

0.93 [0.89-0.97]

0.60

HPV 18

14

18

0.83 [0.69-0.98]

0.87

HPV 26”

1

1

1.00 [1.00-1.00]

1.00

HPV 31

50

50

0.91 [0.84-0.97]

0.50

HPV 33

26

19

0.83 [0.71-0.95]

0.16

HPV 35

15

4

0.41 [0.13-0.69]

0.002

HPV 39

12

9

0.85 [0.69-1.00]

0.25

HPV 45

14

11

0.88 [0.74-1.00]

0.27

HPV 51

22

14

0.77 [0.61-0.92]

0.15

HPV 52

17

14

0.42 [0.20-0.65]

0.50

HPV 53

35

8

0.35 [0.17-0.52]

<.0001

HPV 56

21

21

0.85 [0.73-0.97]

0.50

HPV 58

27

18

0.79 [0.65-0.92]

0.08

HPV 59

18

3

0.27 [0.03-0.52]

0.02

HPV 66

18

14

0.74 [0.56-0.91]

0.29

HPV 68

8

9

0.58 [0.29-0.86]

0.05

HPV 73

10

3

0.30 [0.00-0.62]

0.04

HPV 82‴

1

1

1.00 [1.00-1.00]

1.00

Mixed

163

56

−0.08 [−0.15-0.02]

<.0001

  1. *: Kappa statistic (<.20, poor; 0.21-0.40, weak; 0.41-0.60, moderate; 0.61-0.80, good; 0.81-1.00, very good). ** Measures significance of the difference between LQ and LA. ″: Sample positive for HPV 26 was the same for LQ and LA. ‴: Sample positive for HPV 82 was the same for LQ and LA.