Table 2 Univariate analysis of factors associated with time to positivity in C. albicans BSIs
Variables | Time to positivity ≤36 hs (n=39) | Time to positivity >36 hs (n=50) | P | ||
|---|---|---|---|---|---|
N | % | N | % | ||
Demographic characteristics | |||||
Age, mean years ±SD | 58.4±17.8 | 65.6±14.8 | 0.04 | ||
Male | 25 | 64.1 | 29 | 58.0 | 0.56 |
Underlying conditions | |||||
Charlson ≥ 3 | 23 | 59.0 | 26 | 52.0 | 0.51 |
Rapidly fatal disease (MacCabe) | 26 | 66.7 | 28 | 56.0 | 0.31 |
Diabetes | 6 | 15.4 | 13 | 26.0 | 0.23 |
Neoplasia | 16 | 41.0 | 10 | 20.0 | 0.03 |
Neutropenia | 1 | 2.6 | 2 | 4.0 | 0.44 |
Surgery | 24 | 61.5 | 26 | 52.0 | 0.34 |
Blood transfusion | 21 | 53.8 | 15 | 30.0 | 0.02 |
Conditions related to the clinical course | |||||
APACHE II score ≥ 20 at BSI onset | 11 | 28.2 | 23 | 46.0 | 0.09 |
Adequate antifungal therapy | 13 | 33.3 | 7 | 14.0 | 0.03 |
Source of infection | |||||
Intravascular catheter | 22 | 56.4 | 16 | 32.0 | 0.04 |
Gastrointestinal | 7 | 17.9 | 23 | 46.0 | 0.01 |
Respiratory tract | 5 | 12.8 | 4 | 8.0 | 0.45 |
Urinary tract | 3 | 7.7 | 5 | 10.0 | 0.71 |
Other | 2 | 5.2 | 2 | 4.0 | 0.83 |
Outcomes | |||||
Organ failure | 31 | 79.5 | 38 | 76.0 | 0.70 |
Septic shock | 18 | 46.2 | 20 | 40.0 | 0.56 |
Respiratory failure | 26 | 66.7 | 36 | 72.0 | 0.59 |
Renal failure | 15 | 38.5 | 18 | 36.0 | 0.81 |
Hematologic failure | 1 | 2.6 | 4 | 8.0 | 0.26 |
Hepatic failure | 3 | 7.7 | 5 | 10.0 | 0.71 |
In-hospital mortality | 29 | 74.4 | 41 | 82.0 | 0.38 |