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Table 2 Sensitivity and specificity before (qualitative detection 1 ) and after (quantitative detection 2 ) applying ROC curve analysis

From: Vaginal microbiome in women from Greenland assessed by microscopy and quantitative PCR

Species Qualitative detection1 Quantitative detection2 AUC
  Se (%) 95% CI Sp (%) 95% CI Se (%) 95% CI Sp (%) 95% CI Cut-off/ml Size (%) 95% CI
Atopobium vaginae * 100 95-100 25 15-36 95 88-99 92 83-97 ≥55556 97 95-99
Sneathia sanguinegens 75 64-84 86 76- 93 67 56-77 97 90-100 ≥14127 85 79-90
Leptotrichia amnionii* 86 76-93 59 47- 70 80 69-88 97 90-100 ≥1746 89 83-94
BVAB 1 67 56-77 68 57-79 54 43-66 93 85-98 ≥9841 75 68-82
BVAB 2* 91 83-96 79 68-88 87 78-94 97 90-100 ≥3492 94 90-98
BVAB 3 66 54-76 86 76-93 66 54-76 92 83-97 ≥95 80 74-86
BVAB-TM7 34 24-46 100 95-100 34 24-46 100 95-100 ≥2698 67 62-72
Megasphaera type 1* 86 76-93 59 47-70 81 71-89 99 93-100 ≥41111 88 82-94
Megasphaera type 2 32 22- 43 93 85-98 28 18-39 100 95-100 ≥1111 63 58-69
Eggerthella-like bacterium* 95 88-99 36 25-48 78 68-87 96 88-99 ≥297937 91 86-96
Mobiluncus curtisii 25 16-36 99 93-100 25 16-36 99 93-100 ≥794 62 57-67
Mobiluncus mulieris 20 12-31 93 85- 98 15 8-25 99 93-100 ≥166349 57 52-62
Gardnerella vaginalis* 100 95-100 3 0.3-10 87 78-94 92 83-97 ≥4803175 95 91-98
Mycoplasma hominis 63 52-74 85 75-92 58 47-69 96 88-99 ≥3968 78 71-84
Ureaplasma parvum 51 39-62 49 37- 61 28 18-39 75 64-85 ≥31746 50 42-59
Ureaplasma urealyticum 18 10-28 90 81-96 14 7-24 95 87-98 ≥22381 54 49-59
Finegoldia magna 63 52-74 59 47-70 63 52-74 59 47-70 ≥159 61 52-69
Prevotella spp.* 97 91-100 4 0.8-12 95 88-99 96 88-99 ≥888889 96 92-100
  1. 1Presence versus absence as determined by qPCR.
  2. 2Presence (≥ cut-off/ml) versus absence (< cut-off/ml) with cut-off determined by ROC curve analysis.
  3. A total of 79 participants with Nugent III and 73 with Nugent I were used for the evaluation. Intermediate flora not included. L. iners is excluded from the table because it acts as a negative predictor for BV.
  4. *Bacterial species with area under the ROC curve (AUC) > 85%.