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Table 4 Antifungal susceptibility profile of 179 oral yeast isolates from 851 healthy subjects from Kunming, China

From: Asymptomatic oral yeast carriage and antifungal susceptibility profile of HIV-infected patients in Kunming, Yunnan Province of China

Species (No.) Antifungal agent MIC range (μg/mL) No. of S strains (%)a No. of S-DD strains (%)b No. of R strains (%)c
C. albicans (131) Fluconazole 0.125-64 127 (96.9) 2 (1.5) 2 (1.5)
  Itraconazole 0.031-16 121 (92.4) 2 (1.5) 8 (6.1)
  Voriconazole 0.031-8 129 (98.5) - 2 (1.5)
  Amphotericin B 0.125-1 131 (100.0) - 0 (0)
C. glabrata (17) Fluconazole 0.25-64 15 (88.2) 0 (0) 2 (11.8)
  Itraconazole 0.031-16 6 (35.3) 0 (0) 11 (64.7)
  Voriconazole 0.031-8 16 (94.1)   1 (5.9)
  Amphotericin B 0.5-1 17 (100.0) - 0 (0)
C. krusei (3) Fluconazole 4-64 2 (66.7) 0 (0) 1 (33.3)
  Itraconazole 1-2 0 (0) 0 (0) 3 (100)
  Voriconazole 0.125-2 2 (66.7) - 1 (33.3)
  Amphotericin B 0.5-1 3 (100.0) - 0 (0)
C. tropicalis (4) Fluconazole 0.25-4 4 (100.0) 0 (0) 0 (0)
  Itraconazole 0.031-0.25 2 (50.0) 2 (50.0) 0 (0)
  Voriconazole 0.031-0.063 4 (100.0) - 0 (0)
  Amphotericin B 0.5-1 4 (100.0) - 0 (0)
C. parapsilosis (21) Fluconazole 0.125-2 21 (100.0) 0 (0) 0 (0)
  Itraconazole 0.031-0.25 13 (61.9) 8 (38.1) 0 (0)
  Voriconazole 0.031-0.25 21 (100.0) - 0 (0)
  Amphotericin B 0.25-1 21 (100.0) - 0 (0)
C. lusitaniae (1) Fluconazole 0.25 1 (100.0) 0 (0) 0 (0)
  Itraconazole 0.031 1 (100.0) 0 (0) 0 (0)
  Voriconazole 0.031 1 (100.0) - 0 (0)
  Amphotericin B 1 1 (100.0) - 0 (0)
C. guilliermondii (1) Fluconazole 4 1 (100.0) 0 (0) 0 (0)
  Itraconazole 0.5 0 (0) 1 (100.0) 0 (0)
  Voriconazole 0.063 1 (100.0) - 0 (0)
  Amphotericin B 1 1 (100.0) - 0 (0)
Pichia ohmeri (1) Fluconazole 2 1 (100.0) 0 (0) 0 (0)
  Itraconazole 2 0 (0) 0 (0) 1 (100)
  Voriconazole 0.063 1 (100.0) - 0 (0)
  Amphotericin B 1 1 (100.0) - 0 (0)
  1. a Susceptible (S) strains were defined by MIC ≤8 μg/mL for fluconazole, ≤0.125 μg/mL for itraconazole, <1 μg/mL for voriconazole and ≤ 1 μg/mL for amphotericin B.
  2. b Susceptible-dose dependent (S-DD) strains were defined by MICs between 16 μg/mL and 32 μg/mL for fluconazole and between 0.25 μg/mL and 0.5 μg/mL for itraconazole.
  3. c Resistant (R) strains were defined by MIC ≥64 μg/mL for fluconazole, ≥1 μg/mL for itraconazole and voriconazole, and >1 μg/mL for amphotericin B.