|
Species (No.)
|
Antifungal agent
|
MIC range (μg/mL)
|
No. of S strains (%)a
|
No. of S-DD strains (%)b
|
No. of R strains (%)c
|
|---|
|
C. albicans (131)
|
Fluconazole
|
0.125-64
|
127 (96.9)
|
2 (1.5)
|
2 (1.5)
|
| |
Itraconazole
|
0.031-16
|
121 (92.4)
|
2 (1.5)
|
8 (6.1)
|
| |
Voriconazole
|
0.031-8
|
129 (98.5)
|
-
|
2 (1.5)
|
| |
Amphotericin B
|
0.125-1
|
131 (100.0)
|
-
|
0 (0)
|
|
C. glabrata (17)
|
Fluconazole
|
0.25-64
|
15 (88.2)
|
0 (0)
|
2 (11.8)
|
| |
Itraconazole
|
0.031-16
|
6 (35.3)
|
0 (0)
|
11 (64.7)
|
| |
Voriconazole
|
0.031-8
|
16 (94.1)
| |
1 (5.9)
|
| |
Amphotericin B
|
0.5-1
|
17 (100.0)
|
-
|
0 (0)
|
|
C. krusei (3)
|
Fluconazole
|
4-64
|
2 (66.7)
|
0 (0)
|
1 (33.3)
|
| |
Itraconazole
|
1-2
|
0 (0)
|
0 (0)
|
3 (100)
|
| |
Voriconazole
|
0.125-2
|
2 (66.7)
|
-
|
1 (33.3)
|
| |
Amphotericin B
|
0.5-1
|
3 (100.0)
|
-
|
0 (0)
|
|
C. tropicalis (4)
|
Fluconazole
|
0.25-4
|
4 (100.0)
|
0 (0)
|
0 (0)
|
| |
Itraconazole
|
0.031-0.25
|
2 (50.0)
|
2 (50.0)
|
0 (0)
|
| |
Voriconazole
|
0.031-0.063
|
4 (100.0)
|
-
|
0 (0)
|
| |
Amphotericin B
|
0.5-1
|
4 (100.0)
|
-
|
0 (0)
|
|
C. parapsilosis (21)
|
Fluconazole
|
0.125-2
|
21 (100.0)
|
0 (0)
|
0 (0)
|
| |
Itraconazole
|
0.031-0.25
|
13 (61.9)
|
8 (38.1)
|
0 (0)
|
| |
Voriconazole
|
0.031-0.25
|
21 (100.0)
|
-
|
0 (0)
|
| |
Amphotericin B
|
0.25-1
|
21 (100.0)
|
-
|
0 (0)
|
|
C. lusitaniae (1)
|
Fluconazole
|
0.25
|
1 (100.0)
|
0 (0)
|
0 (0)
|
| |
Itraconazole
|
0.031
|
1 (100.0)
|
0 (0)
|
0 (0)
|
| |
Voriconazole
|
0.031
|
1 (100.0)
|
-
|
0 (0)
|
| |
Amphotericin B
|
1
|
1 (100.0)
|
-
|
0 (0)
|
|
C. guilliermondii (1)
|
Fluconazole
|
4
|
1 (100.0)
|
0 (0)
|
0 (0)
|
| |
Itraconazole
|
0.5
|
0 (0)
|
1 (100.0)
|
0 (0)
|
| |
Voriconazole
|
0.063
|
1 (100.0)
|
-
|
0 (0)
|
| |
Amphotericin B
|
1
|
1 (100.0)
|
-
|
0 (0)
|
|
Pichia ohmeri (1)
|
Fluconazole
|
2
|
1 (100.0)
|
0 (0)
|
0 (0)
|
| |
Itraconazole
|
2
|
0 (0)
|
0 (0)
|
1 (100)
|
| |
Voriconazole
|
0.063
|
1 (100.0)
|
-
|
0 (0)
|
| |
Amphotericin B
|
1
|
1 (100.0)
|
-
|
0 (0)
|
-
a Susceptible (S) strains were defined by MIC ≤8 μg/mL for fluconazole, ≤0.125 μg/mL for itraconazole, <1 μg/mL for voriconazole and ≤ 1 μg/mL for amphotericin B.
-
b Susceptible-dose dependent (S-DD) strains were defined by MICs between 16 μg/mL and 32 μg/mL for fluconazole and between 0.25 μg/mL and 0.5 μg/mL for itraconazole.
-
c Resistant (R) strains were defined by MIC ≥64 μg/mL for fluconazole, ≥1 μg/mL for itraconazole and voriconazole, and >1 μg/mL for amphotericin B.
