Figure 2
From: Contribution of different pneumococcal virulence factors to experimental meningitis in mice
Bacterial loads in the brain and blood of mice i.c. challenged with S. pneumoniae . A. Mice were infected with 102 cfu/mouse of strains TIGR4 (wt, open squares), FP28 (PspC-, closed circles) and FP262 (PspA-, closed triangles). Control mice were inoculated with 105 cfu/mouse of the mutant FP23 (rough, open circles). Animals were sacrificed at different time-points (6 , 24 and 48 h) after infection, and brains were collected to determine the viable counts. Results are represented as mean log (± SD) cfu/brain over time. B. Animals were infected with 102 cfu/mouse of strains TIGR4, FP28, FP262 and FP23. Twenty-four h after infection, blood was collected and subjected to viable counts. Data are shown as log cfu/ml of blood, and horizontal bars represent the mean cfu for each group. For both panels, asterisks indicate statistical significance (*, p < 0.05; Bootstrap method).