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Table 2 Accuracy of L. interrogans serovar Copenhageni MAC ELISA IgM in diagnosis of leptospirosis compared to microscopic agglutination testing in acute, convalescent and paired sera

From: Detection of human leptospirosis as a cause of acute fever by capture ELISA using a Leptospira interrogansserovar Copenhageni (M20) derived antigen

 

Sensitivity%

Specificity%

PPV%

NPV%

 

(CI 95%)

(CI 95%)

(CI 95%)

(CI 95%)

ELISA IgM,

92.3

56.0

35.3

96.6

Acute

(85.7 - 98.9)

(43.7 - 68.3)

(23.5 - 47.1)

(92.05 - 100)

ELISA IgM,

93.3

51.5

63.6

89.5

Convalescent

(87.2 - 99.5)

(39.2 - 63.9)

(51.8 - 75.5)

(81.9 - 97.1)

ELISA IgM,

93.6

37.5

59.2

85.7

Paired

(87.5 - 99.6)

(25.5 - 49.5)

(47.1 - 71.3)

(77.1 - 94.4)

  1. MAC-ELISA, IgM antibody capture enzyme-linked immunoassay.
  2. NPV, Negative Predictive Value, PPV, Positive Predictive Value.
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BMC Infectious Diseases

ISSN: 1471-2334

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