|
Drug; gene
|
MGIT
|
MGIT
|
MIC
|
MIC
|
MIC
|
|---|
|
Susceptible
|
Resistant
|
Susceptible
|
Borderline
|
Resistant
|
|---|
|
susceptible
|
|---|
|
Rifampin; rpoB
| | | | | |
|
wildtype
|
5
|
0
|
4
|
N/A
|
1
|
|
mutation
|
0
|
8
|
0
|
N/A
|
8
|
|
Isoniazid; inhA or katG
| | | | | |
|
wildtype
|
4
|
0
|
2
|
N/A
|
1
|
|
mutation
|
0
|
9
|
0
|
N/A
|
10
|
|
Ethambutol; embB
| | | | | |
|
wildtype
|
6
|
1
|
2
|
4
|
1
|
|
mutation
|
6
|
0
|
1
|
3
|
2
|
|
Ofloxacin; gyrA
| | | | | |
|
wildtype/silent mutation
|
N/A
|
N/A
|
6
|
7
|
N/A
|
|
mutation
|
N/A
|
N/A
|
0
|
0
|
N/A
|
|
Amikacin; rrs or eis
| | | | | |
|
wildtype
|
N/A
|
N/A
|
8
|
4
|
1
|
|
mutation
|
N/A
|
N/A
|
0
|
0
|
0
|
|
Ethionamide; inhA
| | | | | |
|
wildtype
|
N/A
|
N/A
|
5
|
7
|
1
|
|
mutation
|
N/A
|
N/A
|
0
|
0
|
0
|
-
embB mutation included: Glu378Ala in 2 isolates; Met306Val, Met306Ile, Gly406Asp, Gly406Cys, Tyr319Cys in single isolates. Pyrazinamide susceptibility was not performed but pncA mutations included: Val128Gly in 2 isolates; Glu111stop, Asp49Gly, Ser179Ile, and Val169Ala in single isolates. Val128Gly and Val169Ala have not previously been reported. Five isolates (63%) resistant to both isoniazid and rifampin had pncA mutation.
