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Table 5 Representative amino acid sequences of monoclonal TCRBV families within PBMCs and CD4 +, CD8 + T cell populations of LTBI subjects a

From: Molecular characterization of T cell receptor beta variable in the peripheral blood T cell repertoire in subjects with active tuberculosis or latent tuberculosis infection

Subjectsb Vbeta CDR3 BJ Ratioc
J24 (CD4+) BV24 AAMYLCATS SDRVSPL HFGNGTRLTVTED 1.6 22/25
J23 BV20 SGFYLCAWS VQVGWGETQ YFGPGTRLLVLED 2.5 12/21
J24 (CD4+) BV20 SGFYLCAWS TGTGHSPL HFGNGTRLTVTED 1.6 21/25
J28 (CD8+) BV20 SGFYLCAWS TGTGHSPL HFGNGTRLTVTED 1.6 20/24
J38 BV20 SGFYLCAWS TGTGHSPL HFGNGTRLTVTED 1.6 22/25
J32 (CD4+) BV14 SLYFCASS PGTTQETQ YFGSGTRLLVLED 2.5 18/23
J25 BV14 SLYFCASS PGTTQETQ YFGPGTRLTVLED 2.5 15/23
J28 (CD8+) BV14 SLYFCASS RHTGGTEA FFGQGTRLTVVED 1.1 19/30
J29 BV13.2 TSVYFCASS YDENEQ FFGPGTRLTVLED 2.1 16/22
J31 (CD4+) BV13.2 TSVYFCASK TKPVGEQ FFGPGTRLTVLED 2.1 15/23
J42 BV13.1 TSVYFCASS YSAGGPNEQ FFGPGTRLTVLED 2.1 18/25
J34 (CD4+) BV12 TSVYFCAIR KQGDSYEQ YFGPGTRLTVTED 2.7 17/23
J35 BV12 TSVYFCASR VRLITNYGY TFGSGTRLTVVED 1.2 24/24
J39 (CD4+) BV12 TSVYFCATA GGAPGQPQ HFGDGTRLSILED 1.5 16/24
J23 BJ5.1 SALYLCASS LDYSGNTI YFGEGSWLTVVED 1.3 22/27
J25 (CD8+) BJ5.1 SALYLCASS LDYSGNTI YFGEGSWLTVVED 1.3 22/27
J30 BJ5.1 SALYLCASS LDYSGNTI YFGEGSWLTVVED 1.3 22/25
J24 BV3 SMYLCASG PNYYEQ YFGPGTRLTVTED 2.7 23/25
  1. aWhen the GMSP profile of a TCRBV family displayed a single peak, the corresponding PCR products re-amplified, and the CDR3 were sequenced after cloning.
  2. bThe T cell subsets (CD4+ or CD8+) for analysis are indicated in brackets.
  3. cThe amino acid sequences of the max rate of TCRBV families are shown.