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Table 4 Representative amino acid sequences of monoclonal TCRBV families within PBMCs and CD4 +, CD8 + T cell populations of active TB patients a

From: Molecular characterization of T cell receptor beta variable in the peripheral blood T cell repertoire in subjects with active tuberculosis or latent tuberculosis infection

Patientsb Vbeta CDR3 BJ Ratioc
J1 (CD4+) BV24 AAMYLCATS SDRVSPL HFGNGTRLTVTED 1.6 21/25
J16 (CD4+) BV24 AAMYLCATS QDRAKQ YFGPGTRLLVLED 2.1 20/23
J5 BV23 SALYFCASS NTGTSDGY TFGSGTRLTVVED 1.2 21/25
J2 (CD4+) BV23 SALYFCASS NTGTSDGY TFGSGTRLTVVED 1.2 20/23
J2 BV20 SGFYLCAWS TGTGHSPL HFGNGTRLTVTED 1.6 25/26
J5 BV20 SGFYLCAWS TGTGHSPL HFGNGTRLTVTED 1.6 23/26
J5 (CD4+) BV20 SGFYLCAWS TGTGHSPL HFGNGTRLTVTED 1.6 21/26
J15 BV13.2 TSVYFCASS YGPSTGEL FFGEGSRLTVVED 2.2 20/23
J11 (CD8+) BV13.2 TSVYFCASS YSTDEQ YFGPGTRLTVTED 2.7 18/26
J22 BV13.1 TSVYFCASS YWGSDTQ YFGPGTRLTVLED 2.3 17/25
J13 BV12 TSVYFCAIR KQGDSYEQ YFGPGTRLTVTED 2.7 14/22
J17 (CD8+) BV12 TSVYFCAIR KQGDSYEQ YFGPGTRLTVTED 2.7 18/24
J20 (CD4+) BV12 TSVYFCAIR KQGDSYEQ YFGPGTRLTVTED 2.7 17/22
J5 BV5.1 SALYLCASS LDYSGNTI YFGEGSWLTVVED 1.3 20/26
J1 (CD4+) BV5.1 SALYLCASS LDYSGNTI YFGEGSWLTVVED 1.3 21/25
J3 (CD8+) BV5.1 SALYLCASS LDYSGNTI YFGEGSWLTVVED 1.3 19/21
J10 BV3 SMYLCASS LGARLSNQPQ HFGDGTRLSILED 1.5 16/21
J4 (CD8+) BV3 SSNFCSTT LIGRAGATRA YFGPGTRLTVTED 2.7 20/25
  1. aWhen the GMSP profile of a TCRBV family displayed a single peak, the corresponding PCR products re-amplified, and the CDR3 were sequenced after cloning.
  2. bThe T cell subsets (CD4+ or CD8+) for analysis are indicated in brackets.
  3. cThe amino acid sequences of the max rate of TCRBV families are shown.