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Table 2 The frequencies of skewed TCRBV in CD4 +, CD8 + T cells and PBMCs of the subjects with active TB or LTBI a

From: Molecular characterization of T cell receptor beta variable in the peripheral blood T cell repertoire in subjects with active tuberculosis or latent tuberculosis infection

TCRBV families

CD4+ T cells

CD8+ T cells

Total PBMCs

 

Incidence (%)b

Incidence (%)b

Incidence (%)b

1

8

5

7

2

9

8

7

3

14 (35.0)

8

11 (28.2)

4

7

5

7

5.1

15 (37.5)

9

12 (30.8)

5.2

7

9

8

6

8

5

6

7

7

6

4

8

10 (25.0)

7

6

9

7

5

3

10

7

6

8

11

8

3

7

12

24 (60.0)

16 (41.0)

21 (53.8)

13.1

16 (40.0)

12 (30.8)

12 (30.8)

13.2

15 (37.5)

13 (33.3)

15 (38.5)

14

11 (27.5)

8

8

15

9

5

7

16

7

5

2

17

6

6

5

18

10 (25.0)

9

8

19

7

7

5

20

14 (35.0)

8

11 (28.2)

21

7

5

6

22

7

6

5

23

10 (25.0)

7

8

24

16 (40.0)

10 (25.6)

12 (30.8)

Total no. of skewed BV (average ratio for a case)

266 (6.65) c

193 (4.95) c, d

211 (5.41) c, d

No. of subjects examined with normal pattern (ratio, %)

2 (4.76) e

3 (7.14) e

3 (7.14)e

No. of subjects examined

42

42

42

  1. aThe number of TCRBV gene families showing skewed-clone expansion (oligoclonal or monoclonal) is summarized in subjects with active TB or LTBI.
  2. bThe number of samples showing a skewed-clone expansion in total detected samples (percentages of each TCRBV skewed-clone expansion). Sample with normal GMSP (no skewed-clone expansion pattern in any TCRBV families in a subject) are excluded in the percentage calculation, and the greater than or equal 25% percentages are shown only.
  3. cThe average expansion rate of TCRBV gene families was higher in CD4+ T cell subset than in other two cell populations (P < 0.01, 0.05 by χ2 test).
  4. dThere was no significant difference between the two groups (P > 0.05 by χ 2 test). Sample with normal GMSP (no biased-clone expansion pattern) are excluded in the average ratio calculation.
  5. eThe incidence of the normal GMSP was significantly lower in CD4+ T cells than in other two cell populations (P < 0.01 by χ 2 test).