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Table 2 The frequencies of skewed TCRBV in CD4 +, CD8 + T cells and PBMCs of the subjects with active TB or LTBI a

From: Molecular characterization of T cell receptor beta variable in the peripheral blood T cell repertoire in subjects with active tuberculosis or latent tuberculosis infection

TCRBV families CD4+ T cells CD8+ T cells Total PBMCs
  Incidence (%)b Incidence (%)b Incidence (%)b
1 8 5 7
2 9 8 7
3 14 (35.0) 8 11 (28.2)
4 7 5 7
5.1 15 (37.5) 9 12 (30.8)
5.2 7 9 8
6 8 5 6
7 7 6 4
8 10 (25.0) 7 6
9 7 5 3
10 7 6 8
11 8 3 7
12 24 (60.0) 16 (41.0) 21 (53.8)
13.1 16 (40.0) 12 (30.8) 12 (30.8)
13.2 15 (37.5) 13 (33.3) 15 (38.5)
14 11 (27.5) 8 8
15 9 5 7
16 7 5 2
17 6 6 5
18 10 (25.0) 9 8
19 7 7 5
20 14 (35.0) 8 11 (28.2)
21 7 5 6
22 7 6 5
23 10 (25.0) 7 8
24 16 (40.0) 10 (25.6) 12 (30.8)
Total no. of skewed BV (average ratio for a case) 266 (6.65) c 193 (4.95) c, d 211 (5.41) c, d
No. of subjects examined with normal pattern (ratio, %) 2 (4.76) e 3 (7.14) e 3 (7.14)e
No. of subjects examined 42 42 42
  1. aThe number of TCRBV gene families showing skewed-clone expansion (oligoclonal or monoclonal) is summarized in subjects with active TB or LTBI.
  2. bThe number of samples showing a skewed-clone expansion in total detected samples (percentages of each TCRBV skewed-clone expansion). Sample with normal GMSP (no skewed-clone expansion pattern in any TCRBV families in a subject) are excluded in the percentage calculation, and the greater than or equal 25% percentages are shown only.
  3. cThe average expansion rate of TCRBV gene families was higher in CD4+ T cell subset than in other two cell populations (P < 0.01, 0.05 by χ2 test).
  4. dThere was no significant difference between the two groups (P > 0.05 by χ 2 test). Sample with normal GMSP (no biased-clone expansion pattern) are excluded in the average ratio calculation.
  5. eThe incidence of the normal GMSP was significantly lower in CD4+ T cells than in other two cell populations (P < 0.01 by χ 2 test).