Table 1 Poisson regression model showing adjusted and unadjusted associations between identified factors and first paradoxical reactions rates

Sex

Male

86 (55.1)

15 (17.4)

72.5

20.7 (12.5,34.3)

1

0.26

1

0.64

Female

70 (44.9)

17 (24.3)

55.0

30.8 (19.1,49.5)

1.48 (0.74,2.98)

0.83 (0.38,1.81)

Age (years)

0-<15

13 (8.3)

3 (23.1)

9.9

30.4 (9.8,94.2)

2.94 (0.74,11.76)

0.01

2.77 (0.67,11.38)

0.16

15-<60

62 (39.7)

6 (9.7)

58.1

10.3 (4.6,23.0)

1

1

≥60

81 (51.9)

23 (28.4)

59.8

38.4 (25.5,57.9)

3.72 (1.51,9.14)

2.84 (1.12,7.17)

0.03

Lesion type

Ulcer

137 (87.8)

24 (17.5)

116.0

20.7 (13.9,30.9)

1

0.03

1

Nodule

10 (6.4)

4 (40.0)

6.3

63.3 (23.7,168.6)

3.06 (1.06,8.81)

1.98 (0.57,6.91)

0.29

Oedematous

9 (5.8)

4 (44.4)

5.4

73.9 (27.7,196.8)

3.57 (1.24,10.29)

3.44 (1.11,10.70)

0.03

Lesion site

Upper limb

55 (35.3)

11 (20.0)

44.7

24.6 (13.9,44.4)

1

Lower limb

99 (63.5)

21 (21.2)

80.3

25.9 (16.9,39.7)

1.05 (0.51,2.18)

0.60

-

-

Torso

2 (1.3)

0 (0.0)

-

-

-

Lesion position

Proximal

16 (10.3)

2 (12.5)

14.2

14.1 (3.5,56.5)

1

0.35

-

-

Distal

140 (89.7)

30 (21.3)

113.6

26.4 (18.5, 37.8)

1.87 ( 0.45,7.82)

Over a joint

No

91 (58.3)

17 (18.7)

76.2

22.5 (13.9,35.9)

1

0.45

-

-

Yes

65 (41.7)

15 (23.1)

51.5

29.1 (17.6,48.3)

1.31 (0.65,2.61)

Positive margins

No

36 (32.7)

4 (11.0)

32.5

12.3 (4.6,32.8)

1

0.03

-

-

Yes

74 (67.3)

20 (27.0)

56.5

35.4 (22.8,54.8)

2.87 (0.98,8.41)

Any excision

No

42 (27.0)

6 (14.3)

36.5

16.5 (7.4, 36.6)

1

0.20

-

-

Yes

114 (73.0)

26 (22.8)

91.3

28.5 (19.4,41.8)

1.72 (0.71,4.20)

Major excision

No

82 (52.6)

11 (13.4)

71.9

15.3 (8.5,27.6)

1

0.01

1

0.14

Yes

74 (47.4)

21 (28.4)

55.9

37.6 (24.5,57.6)

2.45 (1.18,5.09)

1.78 (0.82,3.87)

Diabetes

No

143 (91.7)

27 (18.9)

118.9

22.7 (15.6,33.1)

1

0.09

1

0.77

Yes

13 (8.3)

5 (38.5)

8.8

56.7 (23.6,136.2)

2.50 (0.96,6.49)

1.19 (0.37,3.89)

Immune suppression

No

145 (93.0)

28 (19.3)

120.0

23.3 (16.1,33.8)

1

0.18

-

-

Yes

11 (7.1)

4 (36.4)

7.7

51.7 (19.4,137.6)

2.21 (0.78,6.31)

Rifampicin

No

9 (5.8)

2 (22.2)

7.4

26.9 (6.7,107.5)

1

0.92

-

-

Yes

147 (94.2)

30 (20.4)

120.3

24.9 (17.4,35.7)

0.93 (0.22,3.88)

Ciprofloxacin

No

55 (35.3)

13 (23.6)

43.5

29.9 (17.4,51.5)

1

0.44

-

-

Yes

101 (64.7)

19 (18.8)

84.3

22.5 (14.5,35.7)

0.75 (0.37,1.53)

Clarithromycin

No

108 (69.2)

24 (22.2)

87.1

27.6 (18.5,41.1)

1

0.40

-

-

Yes

48 (30.8)

8 (16.7)

40.7

19.7 (9.8,39.3)

0.71 (0.32,1.59)

Ethambutol

No

145 (93.0)

28 (19.3)

120.1

23.3 (16.1,33.8)

1

0.17

-

-

Yes

11 (7.1)

4 (36.4)

7.6

52.3 (19.6,139.5)

2.25 (0.79,6.40)

Amikacin

No

151 (96.8)

28 (18.5)

126.0

22.2 (15.3,32.2)

1

<0.001

1

<0.01

Yes

5 (3.2)

4 (80.0)

1.8

228.6 (85.8,609.2)

10.29 (3.61,29.33)

6.33 (2.09,19.18)

Moxifloxacin

No

151 (96.8)

30 (19.9)

124.6

24.1 (16.8,34.4)

1

-

Yes

5 (3.2)

2 (40.0)

3.1

64.0 (16.0,255.8)

2.66 (0.64,11.12)

0.24

-