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Figure 5 | BMC Infectious Diseases

Figure 5

From: Incidence, clinical spectrum, diagnostic features, treatment and predictors of paradoxical reactions during antibiotic treatment of Mycobacterium ulceransinfections

Figure 5

Illustration of histological features representing a paradoxical reaction. a-d: Initial lesion before antibiotic treatment showing a sparse acute inflammatory reaction around necrotic fat and subcutaneous tissue (a) with high numbers of extracellular acid-fast bacilli (in pink) on Wade-Fite stain (b). After 8 weeks of antibiotic treatment showing a paradoxical reaction manifest by a dense inflammatory reaction including multinucleated giant cells (c) and no extracellular acid-fast bacilli seen with Wade-Fite stain (d).

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