Figure 2

Illustration of clinical features representing a wound paradoxical reaction. a-b: Buruli ulcer lesion posterior calf at commencement of antibiotic treatment with induration 40x42 mm diameter (a). Lesion after 5 weeks antibiotic treatment complicated by a paradoxical reaction manifest by increased induration around lesion (60x40 mm diameter), increased serous discharge and new ulceration adjacent to initial lesion (b).