Table 1 Main characteristics of cases and matched controls at time of late sample
Characteristic | Cases | Controls | p-value# |
|---|---|---|---|
(n= 33)* | (n= 71)* | ||
Age, years | |||
median (IQR) | 47 (42, 53) | 45 (39, 49) | 0.139 |
Gender, n(%) | |||
Female | 1 (3%) | 8 (11%) | 0.205 |
Mode of HIV trasmission, n (%) | |||
IDU | 13 (39%) | 21 (30%) | |
Homosexual contacts | 7 (21%) | 18 (25%) | 0.365 |
Heterosexual contacts | 12 (36%) | 24 (34%) | 0.657 |
Other/Unknown | 1 (3%) | 8 (11%) | 0.143 |
Co-infection with HBV or HCV, n (%) | |||
Yes | 16 (48%) | 26 (37%) | 0.224 |
CD4 count, cells/mm3 | |||
Median (IQR) | 550 (451, 730) | 525 (370, 768) | 0.805 |
HIV RNA, log10 copies/mL | |||
Median (IQR) | 2.1 (1.7, 4.0) | 1.7 (1.7, 2.7) | 0.164 |
Median total cholesterol (IQR) | 0.006 | ||
nmol/L | 5.4 (4.6, 6.3) | 4.9 (4.0, 5.6) | |
mg/dL | 209.0 (180.0, 247.0) | 192.0 (155.0, 217.0) | |
Median HDL-cholesterol (IQR) | 0.130 | ||
nmol/L | 2.1 (1.8, 2.3) | 2.3 (1.9, 2.6) | |
mg/dL | 40.0 (35.0, 45.0) | 44.0 (37.0, 51.0) | |
cART-treated before late sample, n (%) | 0.115 | ||
Yes | 29 (88%) | 54 (76%) | |
AIDS diagnosis, n (%) | 0.586 | ||
Yes | 6 (18%) | 16 (23%) | |
Cumulative exposure to NRTI, months | 0.003 | ||
Median (IQR) | 51 (27, 102) | 121 (40, 145) | |
Cumulative exposure to NNRTI, months | 0.021 | ||
Median (IQR) | 3 (0, 27) | 30 (0, 77) | |
Cumulative exposure to PI, months | 0.020 | ||
Median (IQR) | 26 (8, 38) | 52 (11, 89) | |
Calendar year of sample | <.001 | ||
Median (IQR) | 2003 (2001, 2006) | 2008 (2003, 2008) | |
Median duration between late sample and analysis time, months | 3 (2, 12) | 8 (7, 28) | 0.051 |
Prior use of statins°, n (%) | 0.263 | ||
Yes | 5 (15%) | 4 (6%) | |
Body Mass Index§, kg/m2 | 0.366 | ||
Median (IQR) | 23.7 (21.7, 25.8) | 23.1 (21.3, 26.3) | |
eGFR^ (MDRD formula), ml/min/1.73 m2 | 0.637 | ||
Median (IQR) | 92 (80, 116) | 86 (77, 98) |