KIR3DS1/L1 and HLA-Bw4-80I are associated with HIV disease progression among HIV typical progressors and long-term nonprogressors

Table 1 Distribution of KIR gene frequency ¹ among individuals in different groups

KIRgene	²LowCD4	³High CD4	P	⁴High VL	⁵Low VL	P	⁶TP	⁷LTNP	P
KIRgene	(Total 83)	(Total 49)	P	(Total 84)	(Total 48)	P	(Total 83)	(Total 40)	P
	n (%)	n (%)		n (%)	n (%)		n (%)	n (%)
KIR2DL1	80 (96.4)	47 (95.9)	0.615	81 (96.4)	46 (95.8)	0.601	80 (96.4)	40 (100.0)	0.304
KIR2DL2	43 (51.8)	32 (65.3)	0.091	46 (54.8)	29 (60.4)	0.328	43 (51.8)	26 (65.0)	0.117
KIR2DL3	81 (97.6)	46 (93.9)	0.266	82 (97.6)	45 (93.8)	0.253	81 (97.6)	40 (100.0)	0.454
KIR2DL4	82 (98.8)	49 (100.0)	0.629	83 (98.8)	47 (97.9)	0.597	82 (98.8)	40 (100.0)	0.675
KIR2DL5	35 (42.2)	22 (44.9)	0.450	36 (42.9)	21 (43.8)	0.532	35 (42.2)	18 (45.0)	0.458
KIR2DS1	34 (41.0)	26 (53.1)	0.122	36 (42.9)	24 (50.0)	0.270	34 (41.0)	21 (52.5)	0.156
KIR2DS2	23 (27.7)	12 (24.5)	0.424	19 (22.6)	16 (33.3)	0.128	23 (27.7)	9 (22.5)	0.350
KIR2DS3	13 (15.7)	11 (22.4)	0.227	15 (17.9)	9 (18.8)	0.537	13 (15.7)	11 (27.5)	0.097
KIR2DS4	81 (97.6)	46 (93.9)	0.266	82 (97.6)	45 (93.8)	0.253	81 (97.6)	37 (92.5)	0.194
KIR2DS5	26 (31.3)	18 (36.7)	0.326	27 (32.1)	17 (35.4)	0.422	26 (31.3)	14 (35.0)	0.417
KIR2DP1	80 (96.4)	47 (95.9)	0.615	81 (96.4)	46 (95.8)	0.601	80 (96.4)	40 (100.0)	0.304
KIR3DP1	83 (100.0)	48 (98.0)	0.371	84 (100.0)	47 (97.9)	0.364	83 (100.0)	39 (97.5)	0.325
KIR3DL1	81 (97.6)	46 (93.9)	0.266	82 (97.6)	45 (93.8)	0.253	81 (97.6)	37 (92.5)	0.194
KIR3DL2	83 (100.0)	49 (100.0)		84 (100.0)	48 (100.0)		83 (100.0)	40 (100.0)
KIR3DL3	83 (100.0)	49 (100.0)		84 (100.0)	48 (100.0)		83 (100.0)	40 (100.0)
KIR3DS1	22 (26.5)	22 (44.9)	0.025	25 (29.8)	19 (39.6)	0.169	22 (26.5)	18 (45.0)	0.033

¹The frequency of individuals with at least one copy of the 16 KIR genes.
²Low CD4, “low CD4⁺ T cell count” group (CD4⁺ T cell counts ≥ 500 cells/μl); ³High CD4, “High CD4⁺ T cell count” group (CD4⁺ T cell counts<500 cells/μl); ⁴High VL, “high viral load” group (HIV viral load ≥ 10⁴ copies/ml); ⁵Low VL, “low viral load” group (HIV viral load<10⁴ copies/ml); ⁶TP, HIV typical progressors; ⁷LTNP, HIV long-term nonprogressors (9 individuals were excluded for the analysis based on LTNPs or TPs, because of not meeting the criteria of LTNPs or TPs).
n, the number of individuals with each KIR gene in each group; %, the percentage of individuals with each KIR gene in each group.
Data was calculated by from Yates’s correction or Fisher’s exact test.
Bold numbers indicated P value<0.05.

ISSN: 1471-2334