Figure 1

Association of HLA-B gene with HIV disease progression. Shown are results for the comparisons of the frequency of individuals in various study groups carrying a particular gene. (A) HLA-B gene frequencies among the “high CD4⁺ T cell count” group (light grey) and the “low CD4⁺ T cell count” group (dark grey) are shown. The data show that subjects who had at least one copy of the HLA-Bw4-80I gene had higher CD4⁺ T cell counts (P = 0.015). However, HLA-Bw6 homozygotes had lower CD4⁺ T cell counts (P = 0.023). (B) HLA-B gene frequencies among the “high viral load” group (light grey) and the “low viral load” group (dark grey) are shown. (C) HLA-B allele frequencies among TPs (light grey) and LTNPs (dark grey) are shown. The data show that the proportion of people who had at least one copy of the HLA-Bw4-80I gene was higher among LTNPs than among TPs (P = 0.006). However, the proportion of HLA-Bw6 homozygotes was significantly lower among LTNPs than among TPs (P = 0.014).