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Table 4 Risk factors for disease in child contacts of multidrug-resistant tuberculosis: source case and exposure characteristics (n = 102)

From: Risk factors for infection and disease in child contacts of multidrug-resistant tuberculosis: a cross-sectional study

Variable   Total Disease OR p-value Age-adjusted OR p-value
(n = 102) (row %) (95% CI) (95%CI)
(n = 15)
Age of source case (n = 99) 16–25 31 4 (12.9) 1 0.81   
26–35 40 5 (12.5) 0.96 (0.24–3.94)
>35 28 5 (17.9) 1.47 (0.35–6.12)
Gender of source case (n = 101) Female 62 11 (17.7) 1 0.31   
Male 39 4 (10.3) 0.53 (0.16–1.80)
Smoking status of source case (n = 101) Non-smoker 52 8 (15.4) 1 0.88   
Smoker 49 7 (14.3) 0.92 (0.31–2.75)
Alcohol use by source case (n = 101)1 Never drinks 65 6 (9.2) 1 0.04 1 0.07
Drinks alcohol 36 9 (25.0) 3.28 (1.06–10.1) 2.90 (0.90–9.31)
Smear result of source case (n = 99) Negative 9 0 (0) - 0.35   
Positive 90 15 (16.7) -
Smear grade of source case (n = 98) Negative 9 0 (0) - 0.05   
Scanty 8 0 (0) -
1+ 15 5 (33.3) -
2+ 44 9 (20.5) -
3+ 22 1 (4.5) -
HIV status of source case (n = 99) Negative 79 8 (10.1) 1 0.009 1 0.03
Positive 20 7 (35.0) 4.78 (1.45–15.5) 4.07 (1.19–13.8)
CD4 count of source case if HIV-positive (n = 18) <200 7 3 (42.9) 1 0.78   
>200 11 4 (36.4) 0.76 (0.11–5.28)
Relationship of source case to child Parents 38 5 (13.2) 1 0.62   
Grandparent 15 4 (26.7) 2.4 (0.55–10.6)
Uncle or aunt 33 4 (12.1) 0.91 (0.22–3.71)
Other 16 2 (12.5) 0.94 (0.16–5.45)
Duration of exposure between source case and child Less than a month 13 3 (23.1) 1 0.35   
One month to six months 38 7 (18.4) 0.75 (0.16–3.47)
More than six months 51 5 (9.8) 0.36 (0.07–1.77)
Primary caregiver to child Index case 21 2 (9.5) 1 0.46   
Not index case 81 13 (16.0) 1.82 (0.38–8.76)
Frequency of contact between source case and child Daily 93 12 (12.9) 1 0.12   
Less frequently 9 3 (33.3) 3.38 (0.74–15.3)
Intensity of contact between child and source case Sleeps in the same bed 25 3 (12.0) 1 0.47   
Sleeps in the same room 13 1 (7.7) 0.61 (0.06–6.54)
Sleeps in the same house 45 6 (13.3) 1.13 (0.26–4.96)
Sleeps in a different house 19 5 (26.3) 2.62 (0.54–12.7)
  1. 1Regular alcohol use in source case as reported by the parent or legal guardian of the child, OR odds ratio, CI confidence interval.