Skip to main content

Table 5 Clinical and demographic characteristics of patients with and without nephrotoxicity

From: Trough colistin plasma level is an independent risk factor for nephrotoxicity: a prospective observational cohort study

  Patients without nephrotoxicity (n = 76) Patients with nephrotoxicity (n = 26) P Patients without nephrotoxicity (n = 52) Patients with nephrotoxicity (n = 50) P
  Day 7   EOT  
Age, years* 66.5 (24–91) 73 (41–84) 0.036 65 (24–91) 72.5 (30–87) 0.016
Male sex 61 (80.3) 18 (69.2) 0.281 40 (76.9) 39 (49.4) 1
Charlson Index* 4.12 ± 2.58 5.5 ± 2.34 0.031 3.6 ± 2.4 5.36 ± 2.3 0.001
APACHE II 14.9 ± 6.4 14.8 ± 7 0,32 15.3 ± 6 14.2 ± 7 0,16
Clinical status:       
- Severe sepsis 39 (51.3) 9 (34.6) 0.175 24 (46.2) 24 (48) 1
- Shock 7 (9.2) 1 (3.8) 0.457 7 (13.5) 1 (2) 0.06
Acute renal failure at baseline 11 (14.5) 4 (15.4) 1 4 (7.7) 11 (22) 0.052
1CKD at baseline 17 (22.3) 6 (23) 1 11 (21.15) 12 (24) 0.81
Albumin* 2.8 ± 0.62 2.5 ± 0.62 0.047 2.8 ± 0.62 2.6 ± 0.62 0.031
1BMI (Kg/m2)* 25.6 ± 5.9 24.3 ± 5.03 0.26 25.2 ± 5 25.4 ± 6.35 0.75
3CMS total dose (MU)* 35.1 ± 15.15 42 ± 15.84 0.06 97.3 ± 106.35 103.9 ± 78.5 0.047
Duration of CMS treatment, days*     18.7 ± 16.6 21.02 ± 14.42 0.047
4Cmin, mg/mL* 0.78 (0.11-3.2) 3.11 (0.45-5.99) <0.0001 0.7 (0.11-5.7) 1.18 (0.16-5.99) <0.0001
5Cmax, mg/mL* 0.78 (0.15-3) 3.2 (0.68-6.62) <0.0001 0.74 (0.15-6.10) 1.81 (0.16-6.62) <0.0001
Concomitant aminoglycoside use 24 (31.6) 8 (30.8) 1 16 (30.8) 16 (32) 1
Concomitant vancomycin use 8 (10.5) 1 (3.8) 0.442 3 (5.8) 6 (12) 0.314
Concomitant 6NSAID use 11 (14.5) 4 (15.4) 1 3 (5.8) 12 (24) 0.012
Concomitant loop diuretic use 31 (40.8) 15 (57.7) 0.172 16 (30.8) 30 (60) 0.005
Other concomitant nephrotoxic drugs 17 (22.4) 4 (14.4) 0.579 13 (25) 8 (16) 0.33
≥ 2 nephrotoxic drugs 37 (48.7) 13 (50) 1 20 (38.5) 30 (60) 0.047
  1. Data are n (%) except where indicated.
  2. * Median (interquartile range).
  3. ** Mean ± SD.
  4. 1CKD: chronic kidney disease. 2BMI: body mass index. 3CMS:colistinmethanesulfonate sodium. 4Cmin: colistin trough plasma concentrations at steady state. 5Cmqx: colistin maximum plasma concentrations at steady state. 6NSAID: non-steroidal anti-inflammatory drugs.