A cohort study of Chlamydia trachomatis treatment failure in women: a study protocol

BMC Infectious Diseases

Table 1 Specimen collection by study timeline.

Specimen collection and testing										If PCR positive @ d28, 42 or 56
Day	0^d	7	14	21	28	35	42	49	56
Number of swabs collected	4	2	2	2	2	2	2	2	2	4-5
Culture	X									X
PCR^a	X	X	X	X		X		X		X
Chlamydia organism load^a	X	X	X	X	X	X	X	X	X	X
Genotype^a	X	X	X	X	X	X	X	X	X	X
Sequencing^a	X	X	X	X	X	X	X	X	X	X
Y-chromosome^a		X	X	X	X	X	X	X	X	X
β-globin^a	X	X	X	X	X	X	X	X	X	X
Test of cure^b					X		X		X
Az absorption^a		X
Blood	X									X
Rectal swab^c										X
Location	Clinic^e	Clinic^e	Home^f	Home^f	Home^f	Home^f	Home^f	Home^f	Home^f	Clinic^e

^aProcessed in batches throughout the course of the study.
^bChlamydia PCR done in real time to report results back to participants and treat any women diagnosed chlamydia positive.
^cIf anal sex reported.
^dDay 0 = baseline or at time of recruitment.
^eSwabs collected by research nurse and put immediately into the appropriate medium.
^fSelf-collected high-vaginal swabs.
Key: X = specimen processed for this experiment, PCR polymerase chain reaction, Az absorption azithromycin absorption, d day.

ISSN: 1471-2334