NLRC4 regulates Lp replication, but not inflammatory cell recruitment to the lung after aerosolized infection. WT (circles), Nlrc4−/− (squares), and Nlrc4−/−/Tlr5−/− mice (triangles) were exposed to aerosolized Lp Philadelphia-1 by aerosol infection (n = 8-12 for each time point). (A) Lp CFU measured at 4, 24 (1 day), 72 (3 days), and 168 (7 days) hours following infection (B) Lung neutrophil and (C) monocyte counts obtained by bronchoalveolar lavage of the right lung. Combined results from three separate experiments are depicted. Data are mean ± SEM † = p < 0.01 and * = p < 0.05 as determined by one-way ANOVA.