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Table 4 Identification of E protein based amino acid substitutions in JEV WB isolates with potential T-cell epitopes

From: Envelope protein gene based molecular characterization of Japanese encephalitis virus clinical isolates from West Bengal, India: a comparative approach with respect to SA14-14-2 live attenuated vaccine strain

Sl. no.

Identified E protein domains

Amino acid substitutions with positions

Associated HLA alleles#

WB Isolates with amino acid substitutions

IND/12/WB/JEV50

IND/11/WB/JEV47

IND/11/WB/JEV46

IND/11/WB/JEV45

1

Domain I

N2H

-

Y

Y

Y

Y

2

Domain I

N8H

-

-

Y

-

-

3

Domain I

K138E

HLA-A*24

Y

Y

Y

Y

4

Domain I

Q158P

HLA-A*1101, HLA-A*24

Y

-

-

-

5

Domain I

V176I

HLA-A*0101, HLA-A*0301,

Y

Y

Y

Y

HLA-A*1101, HLA-A*6801,

HLA-A*6802, HLA-B*07, HLA-B*51

6

Domain I

A177T

HLA-A*0101, HLA-A*0301,

Y

Y

Y

Y

HLA-A*1101, HLA-A*6801,

HLA-B*07, HLA-B*51

7

Domain II

S64T

HLA-A*0202, HLA-A*0203,

-

Y

-

-

HLA-A*0206, HLA-A*1101,

HLA-A*24, HLA-A*6802,HLA-B*27

8

Domain II

N103K

HLA-A*24

-

-

-

Y

9

Domain II

F107L

HLA-A*1101, HLA-A*24, HLA-B*51

Y

Y

Y

Y

10

Domain II

S123R

HLA-A*0301, HLA-A*1101,

-

Y

-

-

HLA-A*24, HLA-A*6801, HLA-B*27

11

Domain II

A222S

HLA-B*40, HLA-B*44

-

-

-

Y

12

Domain II

G244E

HLA-A*0101, HLA-A*0201,

Y

Y

Y

Y

HLA-A*0301

13

Domain II

G261S

-

Y

Y

Y

Y

14

Domain II

H264Q

HLA-A*0202, HLA-A*0206, HLA-B*51

-

Y

Y

Y

15

Domain II

M279K

HLA-A*0301, HLA-A*1101,

Y

Y

Y

Y

HLA-A*24, HLA-A*6802, HLA-B*07, HLA-

B*40, HLA-B*44

16

Domain III

E306G

HLA-A*0301, HLA-A*1101, HLA-A*24

-

Y

Y

-

17

Domain III

A311R

HLA-A*0301, HLA-A*1101, HLA-B*27

-

-

Y

-

18

Domain III

V315A

-

-

Y

Y

Y

19

Domain III

S327Q

HLA-A*0101, HLA-A*0301,

-

Y

-

-

HLA-A*1101, HLA-A*24

S327T

HLA-A*0101, HLA-A*0301,

-

-

Y

Y

HLA-A*1101, HLA-A*24

20

Domain III

S329T

HLA-A*0301, HLA-A*1101,

-

Y

Y

-

HLA-A*24, HLA-B*51

21

Domain III

S331K

HLA-A*0301, HLA-A*1101,

-

Y

-

-

HLA-A*24, HLA-B*51

22

Domain III

A366S

HLA-A*0101, HLA-A*0201,

-

Y

Y

-

HLA-A*0202, HLA-A*0206,

HLA-A*0301, HLA-A*1101,

HLA-B*40, HLA-B*44

23

Domain III

V372L

-

-

-

-

Y

24

Domain III

M374I

-

-

-

-

Y

25

Domain III

G388E

HLA-A*0301, HLA-A*6802,

-

Y

-

-

HLA-B*27

G388K

HLA-A*0301, HLA-A*1101,

-

-

-

Y

HLA-A*6802, HLA-B*07, HLA-B*27

26

Domain III

D389E

HLA-A*0301, HLA-A*1101, HLA-A*6802, HLA-B*27, HLA-B*40, HLA-B*44

-

-

Y

-

27

Domain III

W396R

-

-

-

-

Y

28

Stem

R416K

-

Y

Y

-

-

29

Stem

G432R

-

-

Y

-

-

30

Stem

R439K

-

-

Y

Y

Y

31

Transmembrane

L463R

-

-

-

Y

-

32

Transmembrane

L467E

-

-

Y

-

-

33

Transmembrane

A481D

-

-

Y

-

-

  1. # Predicted peptide-epitopes with scores were given as Additional file 3 and Additional file 4. Presence of amino acid substitutions in WB isolates associated with HLA alleles was indicated by “Y”.
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BMC Infectious Diseases

ISSN: 1471-2334

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