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Figure 5 | BMC Infectious Diseases

Figure 5

From: Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis

Figure 5

Histopathology in Asc −/− , Nlrp3 −/− , and WT mice with pneumococcal meningitis. Representative brain slides showing neutrophil infiltration in the meninges 30 hours after induction of pneumococcal meningitis in a WT mouse (A), Asc −/− mouse (B) and Nlrp3 −/− mouse (C). Perivascular cuffing 30 hours after induction of pneumococcal meningitis in a WT mouse (D), Asc −/− mouse (E) and Nlrp3 −/− mouse (F), showing frequent intracerebral and subpial hemorrhages associated with neutrophil infiltration; meningeal, perivascular and intracerebral neutrophil influx was scored on a scale 0–4, means of 16 brain slides per mouse in the coronal plane are displayed (WT, n = 11; Asc −/−, n = 8; Nlrp3 −/−, n = 9; G). Sum of intracerebral hemorrhages and subpial hemorrhages per mouse (WT, n = 11; Asc −/−; n = 8; Nlrp3 −/−; n = 9; H).

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