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Table 2 Component costs for each tuberculosis diagnostic test

From: Comparison of laboratory costs of rapid molecular tests and conventional diagnostics for detection of tuberculosis and drug-resistant tuberculosis in South Africa

  Consumables cost per test, in $ (% of total) [uncertainty range] Equipment cost per test, in $ (% of total) [ uncertainty range] Labor * cost per test, in $ (% of total) [uncertainty range] Overhead cost per test, in $ (% of total) [uncertainty range] Total cost per test, in $ [uncertainty range]
Fluorescence smear microscopy $0.36 (10%) [$0.27–$0.45] $0.12 (4%) [$0.09–$0.48] $2.18 (64%) [$1.64–$3.00] $0.74 (22%) [$0.18–$0.93] $3.40 [$2.19–$4.76]
Ziehl-Neelsen light smear microscopy $0.34 (15%) [$0.26–$0.43] $0.11 (5%) [$0.08–$0.45] $1.05 (47%) [$0.88–$1.53] $0.74 (33%) [$0.18–$0.93] $2.25 [$1.40–$3.24]
MGIT culture $8.05 (66%) [$6.04–$8.65] $1.05 (9%) [$0.71–$4.74] $2.17 (18%) [$2.05–$2.50] $0.89 (7%) [$0.66–$1.11] $12.16 [$9.46–$16.99]
Phenotypic DST using MGIT SIRE system $16.22 (61%) [$12.16–$18.71] $2.77 (10%) [$2.08–$13.42] $4.15 (16%) [$3.41–$6.16] $3.26 (12%) [$2.45–$4.07] $26.39 [$20.10–$42.37]
MTBDR plus $14.13 (60%)[$10.37–$17.24] $1.60 (7%) [$4.17–$7.39] $3.46 (15%) [$2.85–$5.13] $4.28 (18%) [$3.21–$5.35] $23.46[$20.61–$35.12]
Xpert MTB/RIF $11.97 (80%) [$11.49–$19.47] $0.93 (6%) [$0.70–$3.99] $1.13 (8%) [$0.94–$4.30] $0.90 (6%) [$0.22–$1.12] $14.93 [$13.36–$28.88]
  1. Abbreviations: MGIT Mycobacterial Growth Indicator 960 automated liquid culture system, DST Drug Susceptibility Testing using MGIT SIRE system.
  2. *Average salary for laboratory technician was $9.07 per hour based on laboratory records. Range of wages from $7.43 to $16.16 were used for sensitivity analysis based on wages of different skill levels of laboratory workers.
  3. Uncertainty range is based on lowest and highest estimates of consumable and equipment components along with range of laboratory volume of testing [e.g. batch size of Xpert testing was varied from 1 sample to 4 samples per run], along with range of salaries for laboratory technicians, and highest and lowest estimates for laboratory overhead.