Contour plots (
) of HI antibody responses in the per protocol immunogenicity cohort against A/H1N1 (A), A/H3N2 (B), and all three vaccine strains (C).
Footnote: HI, hemagglutination-inhibition; GMT ratios for each adjuvanted formulation versus non-adjuvanted vaccine calculated with two-sided 90% Confidence Interval (CI); the lower limits (LL) of CI were transformed into a desirability index between 0 and 1 using a sigmoidal Derringer function; each LL was transformed to a value between 0 and 1, where 0 indicated an undesirable relative immune response, and 1 a highly desirable relative immune response. For A/H1N1 and A/H3N2, an LL equal to 1.5 was transformed in desirability equal to 0.5. The colors range from red (least desirable) to purple (most desirable).