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Table 3 Information available at admission predictivefor ≥ 1 organ failure within one day

From: Age-related differences in symptoms, diagnosis and prognosis of bacteremia

  Patients without organ failure(342 patients;%within this group) Patients with organ failure(290 patients;%within this group) Bivariate analyses OR(95% CI) Multivariate analysis; full maineffects’model*OR(95%CI)
Age ≥ 65 years 204 (59.6) 215 (74.1) 1.94 (1.38-2.73) 1.65 (1.09 - 2.49)
Male gender 137 (40.1) 135 (46.6) 1.30 (0.95 – 1.79)  
No. of comorbid illnesses - - 1.41 (1.23-1.61) 1.19 (1.02 - 1.40)
Corticosteroid on a daily basis1 8 (2.4) 23 (8.0) 3.55 (1.56 – 8.05) 2.75 (1.10 - 6.89)
Cytostatic treatment within last 14 days 1 (0.3) 6 (2.1) 7.10 (0.85 - 59.34)  
Immunosuppressive treatment 1 (0.3) 5 (1.7) 5.90 (0.69 - 50.77)  
Number of symptoms ≥ 5 35 (10.2) 41 (14.2) 1.45 (0.90 – 2.35)  
“Classical symptoms”2 ≥ 3 141 (41.3) 97 (33.7) 0.72 (0.52 - 0.99) 0.67 (0.45 - 0.99)
“Atypical symptoms”3 ≥ 1 151 (44.2) 169 (58.3) 1.77 (1.29 - 2.42)  
Decline in general health (as described in the emergencydepartment) 112 (32.8) 166 (57.2) 2.74 (1.98 - 3.79) 2.28 (1.58 - 3.27)
Heart rate > 90 beats per minute 197 (58.5) 203 (70.7) 1.72 (1.23 - 2.40) 1.50 (1.02 - 2.20)
Fever (≥ 38.5°C) 229 (68.4) 178 (62.2) 0.76 (0.55 - 1.06)  
Hypothermia (< 36°C) 4 (1.2) 6 (2.1) 1.77 (0.50 - 6.35)  
Tachypnoe and/or hyperventilation 78 (22.8) 167 (57.6) 4.60 (3.26 - 6.48) 3.86 (2.64 - 5.66)
Leukocytosis (≥ 15000/μl) 145 (42.4) 118 (40.7) 0.93 (0.68 - 1.28)  
Leukopenia (< 3000/μl) 6 (1.8) 31 (10.7) 6.70 (2.76 - 16.31) 4.16 (1.59 - 10.91)
CRP ≥ 80 mg/L 253 (74.0) 233 (80.3) 1.44 (0.99 - 2.10)  
CRP ≥ 200 mg/L 157 (45.9) 153 (52.8) 1.32 (0.96 -1.80)  
New-onset atrial fibrillation 35 (10.4) 64 (22.1) 2.45 (1.57 - 3.82)  
  1. OR = odds ratio, CI = confidence interval.1Equivalent toprednisolone ≥ 10 mg per day,2“Classical symptoms”: fever/chills, localizedpain, nausea/vomiting, diarrhea, cough, dyspnea, expectoration, urgency,painful voiding, hematuria, skin rash and coma/seizures,3“atypical symptoms”: Malaise, falls, dizziness,syncope, unsteadiness, immobility, acute incontinence of urine or feces,paresis/speaking difficulties, acute confusional state. *Analyses ofinteractions indicated that high age significantly reduced the effect oftachypnea and/or hyperventilation and the effect of number of comorbidillnesses on early organ failure (results not shown).