Table 4 Univariate and multivariate Cox model for 28-day mortality with first-day clinical stage as fixed covariate
Covariables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Age (for each year of increase) | 1.02 | 1.01 – 1.02 | <0.001 | 1.01 | 1.00 – 1.02 | <0.001 |
Sex | ||||||
Female | 1 | Reference | 1 | Reference | ||
Male | 1.07 | 0.90 – 1.28 | 0.446 | 1.02 | 0.84 – 1.23 | 0.829 |
Site | ||||||
Community | 1 | Reference | 1 | Reference | ||
Hospital | 1.41 | 1.18 – 1.69 | <0.001 | 1.38 | 1.10 – 1.72 | 0.005 |
Source of infection | ||||||
Urinary | 1 | Reference | 1 | Reference | ||
Respiratory | 2.53 | 1.89 – 3.39 | <0.001 | 1.75 | 1.25 – 2.45 | 0.001 |
Skin and soft tissues | 1.13 | 0.80 – 1.59 | 0.483 | 1.30 | 0.91 – 1.87 | 0.151 |
Intra-abdominal | 2.20 | 1.57 – 3.09 | <0.001 | 1.60 | 1.10 – 2.32 | 0.013 |
Other infections | 2.03 | 1.55 – 2.66 | <0.001 | 1.72 | 1.29 – 2.30 | <0.001 |
Comorbidities | ||||||
Without comorbidities | 1 | Reference | 1 | Reference | ||
With any comorbidity | 1.64 | 1.33 – 2.03 | <0.001 | 1.06 | 0.84 – 1.33 | 0.644 |
SOFA score (0 – 24, for each unit of increase) | 1.20 | 1.18 – 1.23 | <0.001 | 1.08 | 1.04 – 1.12 | <0.001 |
APACHE II score (0 – 67, for each unit of increase) | 1.11 | 1.09 – 1.12 | <0.001 | 1.05 | 1.03 – 1.07 | <0.001 |
Blood cultures | ||||||
Not requested | 1 | Reference | 1 | Reference | ||
Negative | 1.22 | 0.99 – 1.50 | 0.058 | 1.06 | 0.84 – 1.32 | 0.623 |
Gram-positive bacteria | 1.51 | 1.07 – 2.12 | 0.018 | 1.00 | 0.69 – 1.45 | 0.980 |
Gram-negative bacteria | 1.55 | 1.16 – 2.07 | 0.003 | 1.02 | 0.75 – 1.40 | 0.894 |
Classification of infection (fixed at admission) | ||||||
Infection without sepsis | 1 | Reference | 1 | Reference | ||
Sepsis | 2.08 | 1.40 – 3.09 | <0.001 | 1.40 | 0.93 – 2.09 | 0.105 |
Severe sepsis | 3.23 | 2.21 – 4.73 | <0.001 | 1.50 | 0.99 – 2.26 | 0.052 |
Septic shock | 7.79 | 5.31 – 11.42 | <0.001 | 2.10 | 1.33 – 3.32 | 0.002 |