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Table 2 Univariate and multivariate GEE models for estimating determinants of progression to sepsis, severe sepsis, or septic shock during the first week of hospital stay

From: Clinical course of sepsis, severe sepsis, and septic shock in a cohort of infected patients from ten Colombian hospitals

Covariables Univariate analysis Multivariate analysis
  OR 95% CI P value OR 95% CI P value
Age (for each year of increase) 1.00 (1.00 – 1.01) <0.001 1.00 (1.00 – 1.00) 0.445
Sex   
  Female 1 Reference 1 Reference
  Male 1.07 (1.00 – 1.15) 0.037 0.97 (0.92 – 1.02) 0.236
Site   
  Community 1 Reference 1 Reference
  Hospital 1.12 (1.04 – 1.20) 0.002 1.03 (0.96 – 1.09) 0.409
Source of infection   
  Urinary 1 Reference 1 Reference
  Respiratory 1.53 (1.38 – 1.68) <0.001 1.21 (1.11 – 1.33) <0.001
  Skin and soft tissues 0.81 (0.73 – 0.91) <0.001 0.91 (0.84 – 1.00) 0.041
  Intra-abdominal 1.64 (1.46 – 1.84) <0.001 1.32 (1.20 – 1.46) <0.001
  Other infections 1.33 (1.22 – 1.44) <0.001 1.16 (1.08 – 1.25) <0.001
Comorbidities       
  Without comorbidities 1 Reference 1 Reference
  With any comorbidity 1.30 (1.21 – 1.40) <0.001 1.01 (0.95 – 1.07) 0.774
SOFA score (0 – 24, for each unit of increase) 1.21 (1.20 – 1.22) <0.001 1.16 (1.14 – 1.17) <0.001
APACHE II score (0 – 67, for each unit of increase) 1.08 (1.07 – 1.08) <0.001 1.02 (1.02 – 1.03) <0.001
Blood cultures   
Not requested 1 Reference 1 Reference
Negative 1.17 (1.09 – 1.27) <0.001 0.96 (0.91 – 1.03) 0.281
  Gram-positive bacteria 1.46 (1.28 – 1.66) <0.001 0.99 (0.88 – 1.11) 0.867
  Gram-negative bacteria 1.58 (1.41 – 1.75) <0.001 1.01 (0.93 – 1.11) 0.748