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Table 4 Univariate and multivariate analysis of factors related to inappropriate empirical treatment in community-onset BSI

From: Reappraisal of the outcome of healthcare-associated and community-acquired bacteramia: a prospective cohort study

Variable

Univariate analysis

Multivariate analysis

Inappropriate empirical therapy

RR (95% CI)

P value

OR

RR (95% CI)

P value

No. (%)

Gender

Male

33/195 (17)

Ref.

-

-

-

-

Female

24/144 (17)

1.0 (0.6–1.6)

0.95

-

-

-

Type of acquisition

CA

23/149 (15)

Ref.

-

-

-

-

HCA

34/190 (18)

1.2 (0.7–1.9)

0.5

-

-

-

Ambulatory IV therapy

No

46/300 (15)

Ref.

-

-

-

-

Yes

11/39 (28)

1.8 (1.1–3.2)

0.04

-

-

-

Type of hospital

Tertiary

40/253 (16)

Ref.

-

-

-

-

Community

17/86 (20)

1.25 (0.7–2.1)

0.4

-

-

-

Cancer

No

38/260 (15)

Ref.

-

1,9

1,04-3,78

0,03

Yes

19/79 (24)

1.65 (1.0 –2.7)

0.05

-

-

-

Urinary catheter

No

45/295 (15)

Ref.

-

-

-

-

Yes

12/44 (27)

1.8 (1.1–3.1)

0.05

-

-

-

Central vascular Catheter

No

48/304 (16)

Ref.

-

2,0

1,09-3,81

0,02

Yes

9/35 (26)

1.6 (0.9–3.0)

0.1

-

-

-

Previous antibiotics

No

36/251 (14)

Ref.

-

-

-

-

Yes

21/87 (24)

1.7 (1.1–2.7)

0.03

-

-

-

Previous surgery

No

53/328 (16)

Ref.

-

2,0

1,04-3,78

0,03

Yes

4/11 (36)

2.25 (1.0–5.1)

0.08

-

-

-

Neutropenia

No

53/324 (16)

Ref.

-

-

-

-

Yes

4/15 (27)

1.6 (0.7– 3.9)

0.3

-

-

-

ICU admission

No

50/317 (16)

Ref.

-

-

-

-

Yes

7/22 (32)

2.0 (1.4–3.9)

0.05

-

-

-

Severity of SIRS

Sepsis

45/244 (18)

Ref.

-

-

-

-

Severe sepsis or shock

12/95 (13)

0.7 (0.4–1.2)

0.2

-

-

-

Source of BSI

Urinary tract

8/87 (9)

Ref.

-

-

-

-

Respiratory tract

7/48 (15)

1.6 (0.6–4.1)

0.3

-

-

-

Other source

6/40 (15)

1.6 (0.6–4.4)

0.3

-

-

-

Intraabdominal

15/71 (21)

2.3 (1.1–5.1)

0.03

-

-

-

Unknown

14/65 (21.5)

2.3 (1.1–5.2)

0.03

-

-

-

Catheter

7/24 (29)

3.2 (1.3–7.9)

0.01

-

-

-

Polymicrobial

No

48/318 (15)

Ref.

-0.001

-

-

-

Yes

9/21 (43)

2.8 (1.6–5.0)

-

-

-

Etiology

S. pneumoniae

3/36 (8)

Ref.

-

-

-

-

S. aureus

3/31 (10)

1.2 (0.2–5.3)

0.8

-

-

-

E. coli

13/123 (11)

1.3 (0.4–1.2)

0.7

-

-

-

K. pneumoniae

4/24 (16)

2.0 (0.5–8.1)

0.3

-

-

-

P. aeruginosa

4/14 (29)

3.4 (0.9–13.4)

0.06

-

-

-

CNS

9/24 (37)

4.5 (1.4–15.)

0.01

-

-

-

Enterococcus spp.

7/13 (54)

6.5 (2.0–21.3)

<0.001

-

-

-

Enterobacter spp

6/9 (67)

8.0 (2.5–26.0)

<0.001

-

-

-

Multi-drug- resistant bacteria

No

50/307 (16)

Ref.

-

-

-

-

Yes

7/32 (22)

1.3 (0.7–2.7)

0.4

-

-

-

  1. RR relative risk, CI confidence interval, Ref reference, ICU intensive care unit, CNS coagulase-negative staphylococci.
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BMC Infectious Diseases

ISSN: 1471-2334

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