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Table 4 Univariate and multivariate analysis of factors related to inappropriate empirical treatment in community-onset BSI
| Variable | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| Inappropriate empirical therapy | RR (95% CI) | P value | OR | RR (95% CI) | P value | ||
| No. (%) | |||||||
| Gender | Male | 33/195 (17) | Ref. | - | - | - | - |
| Female | 24/144 (17) | 1.0 (0.6–1.6) | 0.95 | - | - | - | |
| Type of acquisition | CA | 23/149 (15) | Ref. | - | - | - | - |
| HCA | 34/190 (18) | 1.2 (0.7–1.9) | 0.5 | - | - | - | |
| Ambulatory IV therapy | No | 46/300 (15) | Ref. | - | - | - | - |
| Yes | 11/39 (28) | 1.8 (1.1–3.2) | 0.04 | - | - | - | |
| Type of hospital | Tertiary | 40/253 (16) | Ref. | - | - | - | - |
| Community | 17/86 (20) | 1.25 (0.7–2.1) | 0.4 | - | - | - | |
| Cancer | No | 38/260 (15) | Ref. | - | 1,9 | 1,04-3,78 | 0,03 |
| Yes | 19/79 (24) | 1.65 (1.0 –2.7) | 0.05 | - | - | - | |
| Urinary catheter | No | 45/295 (15) | Ref. | - | - | - | - |
| Yes | 12/44 (27) | 1.8 (1.1–3.1) | 0.05 | - | - | - | |
| Central vascular Catheter | No | 48/304 (16) | Ref. | - | 2,0 | 1,09-3,81 | 0,02 |
| Yes | 9/35 (26) | 1.6 (0.9–3.0) | 0.1 | - | - | - | |
| Previous antibiotics | No | 36/251 (14) | Ref. | - | - | - | - |
| Yes | 21/87 (24) | 1.7 (1.1–2.7) | 0.03 | - | - | - | |
| Previous surgery | No | 53/328 (16) | Ref. | - | 2,0 | 1,04-3,78 | 0,03 |
| Yes | 4/11 (36) | 2.25 (1.0–5.1) | 0.08 | - | - | - | |
| Neutropenia | No | 53/324 (16) | Ref. | - | - | - | - |
| Yes | 4/15 (27) | 1.6 (0.7– 3.9) | 0.3 | - | - | - | |
| ICU admission | No | 50/317 (16) | Ref. | - | - | - | - |
| Yes | 7/22 (32) | 2.0 (1.4–3.9) | 0.05 | - | - | - | |
| Severity of SIRS | Sepsis | 45/244 (18) | Ref. | - | - | - | - |
| Severe sepsis or shock | 12/95 (13) | 0.7 (0.4–1.2) | 0.2 | - | - | - | |
| Source of BSI | Urinary tract | 8/87 (9) | Ref. | - | - | - | - |
| Respiratory tract | 7/48 (15) | 1.6 (0.6–4.1) | 0.3 | - | - | - | |
| Other source | 6/40 (15) | 1.6 (0.6–4.4) | 0.3 | - | - | - | |
| Intraabdominal | 15/71 (21) | 2.3 (1.1–5.1) | 0.03 | - | - | - | |
| Unknown | 14/65 (21.5) | 2.3 (1.1–5.2) | 0.03 | - | - | - | |
| Catheter | 7/24 (29) | 3.2 (1.3–7.9) | 0.01 | - | - | - | |
| Polymicrobial | No | 48/318 (15) | Ref. | -0.001 | - | - | - |
| Yes | 9/21 (43) | 2.8 (1.6–5.0) | - | - | - | ||
| Etiology | S. pneumoniae | 3/36 (8) | Ref. | - | - | - | - |
| S. aureus | 3/31 (10) | 1.2 (0.2–5.3) | 0.8 | - | - | - | |
| E. coli | 13/123 (11) | 1.3 (0.4–1.2) | 0.7 | - | - | - | |
| K. pneumoniae | 4/24 (16) | 2.0 (0.5–8.1) | 0.3 | - | - | - | |
| P. aeruginosa | 4/14 (29) | 3.4 (0.9–13.4) | 0.06 | - | - | - | |
| CNS | 9/24 (37) | 4.5 (1.4–15.) | 0.01 | - | - | - | |
| Enterococcus spp. | 7/13 (54) | 6.5 (2.0–21.3) | <0.001 | - | - | - | |
| Enterobacter spp | 6/9 (67) | 8.0 (2.5–26.0) | <0.001 | - | - | - | |
| Multi-drug- resistant bacteria | No | 50/307 (16) | Ref. | - | - | - | - |
| Yes | 7/32 (22) | 1.3 (0.7–2.7) | 0.4 | - | - | - | |
