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Table 4 Univariate and multivariate analysis of factors related to inappropriate empirical treatment in community-onset BSI

From: Reappraisal of the outcome of healthcare-associated and community-acquired bacteramia: a prospective cohort study

Variable Univariate analysis Multivariate analysis
Inappropriate empirical therapy RR (95% CI) P value OR RR (95% CI) P value
No. (%)
Gender Male 33/195 (17) Ref. - - - -
Female 24/144 (17) 1.0 (0.6–1.6) 0.95 - - -
Type of acquisition CA 23/149 (15) Ref. - - - -
HCA 34/190 (18) 1.2 (0.7–1.9) 0.5 - - -
Ambulatory IV therapy No 46/300 (15) Ref. - - - -
Yes 11/39 (28) 1.8 (1.1–3.2) 0.04 - - -
Type of hospital Tertiary 40/253 (16) Ref. - - - -
Community 17/86 (20) 1.25 (0.7–2.1) 0.4 - - -
Cancer No 38/260 (15) Ref. - 1,9 1,04-3,78 0,03
Yes 19/79 (24) 1.65 (1.0 –2.7) 0.05 - - -
Urinary catheter No 45/295 (15) Ref. - - - -
Yes 12/44 (27) 1.8 (1.1–3.1) 0.05 - - -
Central vascular Catheter No 48/304 (16) Ref. - 2,0 1,09-3,81 0,02
Yes 9/35 (26) 1.6 (0.9–3.0) 0.1 - - -
Previous antibiotics No 36/251 (14) Ref. - - - -
Yes 21/87 (24) 1.7 (1.1–2.7) 0.03 - - -
Previous surgery No 53/328 (16) Ref. - 2,0 1,04-3,78 0,03
Yes 4/11 (36) 2.25 (1.0–5.1) 0.08 - - -
Neutropenia No 53/324 (16) Ref. - - - -
Yes 4/15 (27) 1.6 (0.7– 3.9) 0.3 - - -
ICU admission No 50/317 (16) Ref. - - - -
Yes 7/22 (32) 2.0 (1.4–3.9) 0.05 - - -
Severity of SIRS Sepsis 45/244 (18) Ref. - - - -
Severe sepsis or shock 12/95 (13) 0.7 (0.4–1.2) 0.2 - - -
Source of BSI Urinary tract 8/87 (9) Ref. - - - -
Respiratory tract 7/48 (15) 1.6 (0.6–4.1) 0.3 - - -
Other source 6/40 (15) 1.6 (0.6–4.4) 0.3 - - -
Intraabdominal 15/71 (21) 2.3 (1.1–5.1) 0.03 - - -
Unknown 14/65 (21.5) 2.3 (1.1–5.2) 0.03 - - -
Catheter 7/24 (29) 3.2 (1.3–7.9) 0.01 - - -
Polymicrobial No 48/318 (15) Ref. -0.001 - - -
Yes 9/21 (43) 2.8 (1.6–5.0) - - -
Etiology S. pneumoniae 3/36 (8) Ref. - - - -
S. aureus 3/31 (10) 1.2 (0.2–5.3) 0.8 - - -
E. coli 13/123 (11) 1.3 (0.4–1.2) 0.7 - - -
K. pneumoniae 4/24 (16) 2.0 (0.5–8.1) 0.3 - - -
P. aeruginosa 4/14 (29) 3.4 (0.9–13.4) 0.06 - - -
CNS 9/24 (37) 4.5 (1.4–15.) 0.01 - - -
Enterococcus spp. 7/13 (54) 6.5 (2.0–21.3) <0.001 - - -
Enterobacter spp 6/9 (67) 8.0 (2.5–26.0) <0.001 - - -
Multi-drug- resistant bacteria No 50/307 (16) Ref. - - - -
Yes 7/32 (22) 1.3 (0.7–2.7) 0.4 - - -
  1. RR relative risk, CI confidence interval, Ref reference, ICU intensive care unit, CNS coagulase-negative staphylococci.