Table 5 Descriptive immunogenicity based on HI antibody titers in the per-protocol cohort for immunogenicity
Parameter | Vaccine | Day | N | A/California/7/2009 (H1N1) | A/Victoria/210/2009 (H3N2) | B/Brisbane/60/2008 (Victoria) | B/Brisbane/3/2007 (Yamagata) |
|---|---|---|---|---|---|---|---|
GMTs, value (95% CI) | QIV | Day 0 | 1801 | 14.7 | 34.0 | 73.8 | 101.4 |
(13.8, 15.6) | (31.8, 36.3) | (69.1, 78.8) | (94.5, 108.8) | ||||
Day 21 | 1809 | 201.1 | 314.7 | 404.6 | 601.8 | ||
(188.1, 215.1) | 296.8, 333.6) | (386.6, 423.4) | (573.3, 631.6) | ||||
TIV-Vic | Day 0 | 605 | 15.6 | 38.1 | 73.6 | 100.9 | |
(14.1, 17.3) | (34.1, 42.7) | (65.5, 82.8) | (89.3, 113.9) | ||||
Day 21 | 608 | 218.4 | 298.2 | 393.8 | 386.6 | ||
(194.2, 245.6) | (268.4, 331.3) | (362.7, 427.6) | (351.5, 425.3) | ||||
TIV-Yam | Day 0 | 530 | 14.4 | 35.7 | 71.7 | 99.8 | |
(12.9, 16.0) | (31.6, 40.3) | (63.4, 81.0) | (87.7, 113.5) | ||||
Day 21 | 534 | 213.0 | 340.4 | 258.5 | 582.5 | ||
(187.6, 241.9) | (304.3, 380.9) | (234.6, 284.8) | (534.6, 634.7) | ||||
SPR, % (95% CI) | QIV | Day 0 | 1801 | 28.5% | 53.6% | 79.0% | 83.0% |
(26.5, 30.7) | (51.2, 55.9) | (77.1, 80.9) | (81.1, 84.7) | ||||
Day 21 | 1809 | 91.3% | 96.8% | 98.8% | 99.1% | ||
(89.9, 92.5) | (95.9, 97.6) | (98.2, 99.3) | (98.5, 99.5) | ||||
TIV-Vic | Day 0 | 605 | 27.6% | 58.3% | 78.8% | 82.1% | |
(24.1, 31.4) | (54.3, 62.3) | (75.4, 82.0) | (78.9, 85.1) | ||||
Day 21 | 608 | 91.8% | 95.9% | 98.5% | 97.9% | ||
(89.3, 93.8) | (94.0, 97.3) | (97.2, 99.3) | (96.4, 98.9) | ||||
TIV-Yam | Day 0 | 530 | 26.2% | 53.8% | 77.7% | 83.2% | |
(22.5, 30.2) | (49.4, 58.1) | (74.0, 81.2) | (79.7, 86.3) | ||||
Day 21 | 534 | 92.7% | 96.8% | 96.1% | 99.6% | ||
(90.2, 94.8) | (95.0, 98.1) | (94.1, 97.5) | (98.7, 100) | ||||
SCR, % (95%) | QIV | Day 21 | 1801 | 77.5% | 71.5% | 58.1% | 61.7% |
(75.5, 79.4) | (69.3, 73.5) | (55.8, 60.4) | (59.5, 64.0) | ||||
TIV-Vic | Day 21 | 605 | 77.2% | 65.8% | 55.4% | 45.6% | |
(73.6, 80.5) | (61.9, 69.6) | (51.3, 59.4) | (41.6, 49.7) | ||||
TIV-Yam | Day 21 | 530 | 80.2% | 70.0% | 47.5% | 59.1% | |
(76.5, 83.5) | (65.9, 73.9) | (43.2, 51.9) | (54.7, 63.3) | ||||
SCF, value (95%) | QIV | Day 21 | 1801 | 13.69 | 9.28 | 5.48 | 5.93 |
(12.70, 14.76) | (8.64, 9.96) | (5.12, 5.85) | (5.53, 6.36) | ||||
TIV-Vic | Day 21 | 605 | 13.92 | 7.84 | 5.37 | 3.84 | |
(12.23, 15.84) | (6.93, 8.88) | (4.75, 6.06) | (3.42, 4.30) | ||||
TIV-Yam | Day 21 | 530 | 14.88 | 9.52 | 3.60 | 5.84 | |
(12.91, 17.16) | (8.33, 10.89) | (3.25, 3.98) | (5.13, 6.65) |