Figure 1

Time course of antiviral treatments and events. The viral loads of adenovirus (dashed) and HCMV are depicted as DNA copies per ml EDTA blood. The durations of treatments with ganciclovir, foscarnet and cidofovir are shown as black boxes and with maribavir as grey boxes, respectively. Ribavirin and leflunomide are presented as blank boxes. The boost with selected CD34+ cells is depicted as black star. The administration of adenovirus-specific T-cells is illustrated by a white star. Tx, transplantation; UL97, HCMV UL97 kinase; wt, wild type; pol, HCMV polymerase (UL54). Mutations detected by direct genotyping from the specimens are shown in the single letter code (L592S, lysine at amino acid 595 to serine). The mutation H411N (brackets) was detected by cloning but not by direct genotyping. ADV, adenovirus; n.d., not detected.