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Table 3 DNA and CD4 evolution in 86 patients followed from the T1 to the T2 time point and detection of residual viraemia at T2

From: A stable CC-chemokine receptor (CCR)-5 tropic virus is correlated with the persistence of HIV RNA at less than 2.5 copies in successfully treated naïve subjects

Patients (n)**

Stable X4 (22)

Stable R5 (51)

Switch to X4 (6)

Switch to R5 (7)

CD4 T1a cells/mm3

431 (130 – 950)

560 (54 – 1170)

600 (330 – 860)

420 (315 – 890)

CD4 T2a cells/mm3

520 (170 – 1110)

615 (92 – 1291)

540 (290 – 970)

535 (420 – 740)

HIV DNA T1a Copies/106PBMCs

41 (<5 – 657)

95 (<5 – 892)

75.5 (<5 – 532)

196 (18 – 424)

HIV DNA T2a Copies/106PBMCs

50.5 (<5 – 448)

83 (<5 – 469)

31 (<5 – 412)

70 (7 – 147)

HIV RNA <2,5 copies/ml (n/total n patients and percentage)b

2/22 (9.1%)

19/51 (37.2%)

4/6 (66.7%)

1/7 (14.3%)

  1. aExpressed as median and range.
  2. b Pearson chi2 (3)=11.5664, P = 0.0009).
  3. ** The stability of the tropism (stable X4 plus stable R5 vs switch to R5 plus switch to X4) was significant p< 0.0001.